38 REPORT* ON 



eruption of plaques. The stallion, according to our observations, 

 presents the most symptoms. The only symptom that can be relied 

 upon according to Schneider and Buffard is an cedematous condi- 

 tion o the extremity o the penis, which causes obliteration of 

 the folds of mucous-membrane round the orifice of the urethra. 

 The mucous-membrane of the raeatus-urinariusis everted. (Edema 

 of the prepuce becomes developed later. The cutaneous plaques 

 are very rare in both sexes. In those cases in which the male is 

 susceptible to the disease, and this is rare, the eruption of symp- 

 toms is similar to that which occurs in the horse. Emaciation is 

 very marked, as also engorgement of the sheath and scrotum, and 

 paralysis follows in due course. 



The symptoms which follow the inoculated disease, in the 

 small country-bred donkey, are most marked at the seat of the 

 subcutaneous injection where a primary and later a secondary 

 diffused swelling forms, a period of some eight days occurring 

 between the successive events. In one case the eruption of 

 subcutaneous plaques commenced on the 33rd day after inoculation 

 and the 10th and last on the 50th day. The m. m. of the meatus- 

 urinarius became everted, but no further symptoms developed up 

 to the 217th day. 



Section V DIAGNOSIS. 



In order to come to an absolute diagnosis, it will be necessary 

 to follow up two lines of observation : 



(*') A clinical examination, (it) microscopical examination of 

 certain body fluids for the presence of the parasite. The eruption 

 of symptoms in a case of Dourine usually appear in the following 

 sequence: (Edema of the genital organs, enlargement of the 

 lymphatic and other glands, eruption of plaques or urticaria, pro- 

 gressive emaciation, tenderness over the loins, nervous complica- 

 tions, but may in some cases follow an erratic course. Should any 

 of the above symptoms be observed in equines, suspicion should at 

 once be aroused as to the presence of Dourine, Surra or some other 

 contagious disease. 



(i) Clinical. If the early manifestations in the stallion or 

 mare have been observed, and attention drawn to the probable 



