PAOR 



SBCTION 1. Introduction . ' ....... 1 



i, II. Precis of casea ........ 3 



(a) Naturally acquired or spontaneous .... 8 



(h) Experimental ....... .7 



SECTION III.- Facts bearing on the etiology of Dourine: 



(i) Period of incubation ....... 14 



iii) Period between covering or inoculation and appearance 



of first plaque ....... 17 



(iii) The period of disease during which the eruption of plaques 



takes place .... . . 20 



(iv) Region! of the body on which plaques make their 



appearance ' . . . . . . .21 



(v) Plaques . . ....... 22 



(vi) The length of the individual paroxysms and inter- 



missions ..... ... 24 



(vii) Persistence of cutaneous plaques . .... 25 



(viii) Day after covering or inoculation on which weakness 



in the loins or paraplegia was observed . . .27 



(ix) Trypanosomata in the vaginal mucus . , . .28 

 (x) Exciting causes which frequently bring about a primary 



or a further eruption of plaques . . . .30 



SECTION IV. Symptoms ........ 31 



V. Diagnosis ......... 38 



VI. Course and prognosis ....... 45 



VII. Means by which the disease may be propagated . . 46 



VIII. Susceptibility of different animals ..... 47 



IX. Pathological Anatomy ....... 43 



XI. Notes on the life-history of the trypanosoma . . .53 

 (i) The trypanosoma, the 'materies morbi' of Dourine . 53 



(ii) Mode of entry and subsequent generalization of the 



organism ........55 



(iii) Where does the trypanosoma rest during the prolonged 

 latent period characterized by slight tumefaction of 

 the penile sheath ? . . . . . . .56 



(iv) What is a plaque ? ....... 56 



(v) What is the primary cause of a plaque P . . .67 

 (vi) What changes take place in the form of the trypauosoma 



during the persistence of n plaque P . . . .58 



(vii) In what form do trypanosomata leave plaques, and again 



enter the general circulation P ..... 61 



(viii) Reappearance of a plaque after an interval of a few days 



on the site of the first one . .62 



