80 BEPORT ON DOURINR. 



XIII, 6 1 hours post-mortem. On the 13th September a swelling 

 measuring 5 X 4 X O f 2 5 inches was present at the seat of inoculation, 

 on the following day it had decreased considerably, and after about 70 

 hours' had become absorbed. No symptom was noted between the 

 latter date and October 12th, a period of 27 days. Patches of 

 leucoderma about the anus and vulva became apparent and were 

 noted for the first time on October 13th. As no secondary swelling 

 occurred at the seat of inoculation, it would appear as if the injected 

 fluid found its way into the general circulation and that a general 

 infection took place and not a localized one as in the case of the other 

 animals. No vesicular exanthema has developed, as this mare 

 has not been covered by any stallion and no external manifestation 

 had developed. Therefore the leucodermic patches on the anus and 

 vulva must have been due to the trypanosoma in the general circu- 

 lation. No eruption of plaques has taken place or other symptom 

 of Dourine except the ones noted. 



Tadgir. From the arrival of this animal in the hills after 

 a march of 28 miles on April 9th, 1904, no plaques made their 

 appearance on the cutaneous surface of the body until 24th May, 

 when three were visible on the same morning ; disseminated urti- 

 caria was observed on the left side of the neck on 21st June and 

 persisted for some days. During the month of July, four plaques 

 were noted, viz., Nos. 45 to 47, the latter reappearing and persisting 

 for a period of eight days ; in addition, the cadema of the sheath and 

 under-surface of the abdomen persisted and the off hock and fetlock 

 were swollen. The latter symptoms were stationary daring the 

 following month, but no fresh plaques appeared until September, 

 when two were noted, and up to the middle of October two fresh 

 ones have appeared, Nos. 50 and 51. 



Temperature scarcely varied from between 37 and 38 C. It 

 was calculated that the disease had already existed for 232 days on 

 April 3rd, 1903, on which latter date No. 1 plaque made its appear- 

 ance, and on March 21st, 1904, the 590th day, just before this 

 report was submitted, 40 plaques had made their appearance. At 

 this date, October 15th, 798 days since the first symptoms of 

 Dourine were observed, fresh plaques are still erupting and 

 persist, 



