Vi APPENDIX. 



of the abdomen of this animal. At first cederra would appear in a part, 

 increase, then gradually decrease and finally disappear, leaving no trace be- 

 hind, occupying some 8 or 9 days. After a repetition on several occasions, a 

 certain amount of thickening was left which was not absorbed before a fresh 

 infiltration took place, especially after an increase of the local temperature had 

 been present. This see-saw in the amount of swelling and osdema present in 

 the affected structures has been a constant feature not only in the course of 

 Silngarth's c;ise, but in most other of the Dourine-affected animals which have 

 passed through our bauds. 



No disseminated urticarial eruption was noted in this case, which in several 

 of the animals was such a marked feature, but a vesicular form of eruption 

 appeared in November 1903 implicating more or less the skin of the whole body ; 

 it gradually increased in amount from the 17th to the 21st of the month, re- 

 mained stationary until the 24th, then commenced to fade, finally disappearing 

 on December 1st, leaving small scars on each spot invaded. Twenty-four hours 

 after their appearance, the vesicles burst and discharged a clear, glairy, and 

 albuminous straw-coloured material having the consistency of white of egg, 

 but no trypanosomata were discovered in the collected fluid submitted to 

 microscopical examination. Up to the time of writing, this animal's tempera- 

 ture has been recorded twice daily for a period of ten months, during which 

 time it has seldom varied from a minimun of 36'6 A.M. and a maximum of 

 S8'0 C. P.M. On. three occasions evening temperatures of 38'6, 38'7, and 

 38'8 have been noted, and in each instance on the following morning a consider- 

 able increase in the oedema involving the scrotum and under-surface of the 

 abdomen was observed to have taken place, which might account for the rise. 

 The maximum temperature recorded was 39'6 C. and this was registered at 

 Bareilly on the evening of the animal's arrival from Muktesar, after a march 

 of ten miles a day for three days in succession. There is no weakness evinced 

 when pressure is made over the loins, and no lameness observable at the walk 

 or when the animal is exercised at the trot. The cedema of the sheath has now 

 become organized, the tissues of the anterior portion of the scrotum are slightly 

 thickened and there is slight oadema on the under-surface of the abdomen in 

 front of the sheath. 



