APPENDIX. Xlll 



Between 25th October and December 18th, an Interval of 54 days, no further 

 were seen, but witbin the next month five plaquei appeared on the aides of the 

 abdomen and B. flunks. 



Several mares were covered by this stallion during the first half of May 

 1903 ; Mare II on May 8th, and Maro V (three coverings) between the llth 

 and 15th. The semen on each occasion was found to contain numerous sper- 

 matozoa, but no mature trypanosomata were ever discovered in the numerous 

 fresh specimens submitted to microscopical examination. 



The following details with regard to the most important symptoms noted 

 during the course of the case have been collated for the sake of brevity. 



May 8th, 1902. An ulcer on the anterior surface at the root of the free 

 portion of the penis was observed by the Veterinary Assistant when mare II 

 was covered. It persisted for some days and finally healed on May 20th. No 

 trypanosomata wero observed in specimens of scrapings from the ulcer submit- 

 ted to examination. (Photo IX.) 



On the 29th June 1903, a somewhat thick muscular fold or ring was 

 observed to have been formed by the sheath at the root of the penis, this had a 

 tendency to produce phymosis, but gradually disappeared without producing 

 severe symptoms. About the same date the external inguinal glands became 

 somewhat enlarged and that on the left side was felt to be bard on palpation. 

 These conditions persisted for several months, but on the 12th January 1904 

 the glands wero normal in size and consistency. The submaxillary glands, 

 however, were not observed to be involved at any time during the. course 

 of the case. 



The teste which previous to the middle of July had remained perfectly 

 healthy, as far as external manipulation could decide, then became hard and 

 the right organ more so than the left. Six months later they appeared to have 

 become irregular in shape and were then harder than normal. 



In addition to the cutaneous plaques observed from time to time which are 

 usually well defined and isolated, other forms of eruptions were noted. On 

 the 15th July 1903, a vesicular form of eruption appeared on the head, neck 

 and shoulders, which after 24 hours discharged a clear, glairy and sticky straw 

 coloured fluid, which caused the hair in close proximity to become matted ; 

 this form only persisted for 48 hours and then disappeared. In this fluid no try- 

 panosomata could be found. A second form, the true disseminated urticarial, 

 appeared on'three different occasions. Both sides of the neck were thickly 

 invaded on the 28th August, but the eruption had entirely disappeared after a 

 period of 30 hours. On the second occasion, 19th September, both sides of the . 

 body and abdomen were implicated, this eruption attained a maximum on the 

 evening of the 20tb, persisted during the 21st to 24th inclusive and finally 

 disappeared on the 25th September. On the third occasion, October 10th, the 

 right and left shoulders were the seat of the disseminated urticaria more or 

 less confluent in patches, the size of a man's hand but evanescent in character, 

 for in a few hours it commenced to fade, and after 24 from the onset no sign 

 was left. 



The oedema of the sheath aud scrota! tissues, the first symptom in August 

 1902, which drew attention to the probable cause of the disease, remained 



S 



