xviii APPENDIX. 



repeated scarification. Suppuration followed and considerable swelling of the 

 parts existed until the time of death, 12th October 1903. 



On the evening of the 10th July, 18 days after serving mare 1 on the first 

 occasion, the temperature which was 37'6 C. in the morning rose in the 

 evening to 39'1 C., and on the following morning a plaque was observed on 

 the left side of the body involving the skin over the ribs ; from this date until 

 the 4th October 1903, some 18 plaques^ made their appearance on different 

 parts of the body, at intervals; and on several occasions there were also localized 

 eruptions of urticaria, which persisted for several days and then faded. On 

 another occasion, 9th September, an cedematous swelling was noted involving 

 the subcutaneous tissues in front of the trachea, from the lower edge of the 

 thyroid cartillage and extending down on the front of the chest, this persisted 

 for a period of three days and then became absorbed, no dyspncea developed as a 

 consequence. 



On the morning of the 7th October, the animal was found to show marked 

 symptoms of weakness in the hind quarters and on the next day was unable to 

 stand, but 24 hours later, with assistance was raised and able to maintain 

 the standing position, but with some difficulty. At this time the cedematous 

 swelling extended upwards towards the peringeum, and haemoglobinuria 

 appeared, later the R. hind extremity became swollen and cedematous swelling 

 appeared on the left side of the neck, and 'the tissues surrounding the anus 

 became infiltrated and cedematous. At this period the animal was off feed, and 

 unable to rise from its bed. 



On the morning on which death occurred plaque No. 16 reappeared on the 

 left side of the crest. 



Autopsy Three hours after death : 



On removal of the skin, examination of the seat of No. 16 plaque revealed 

 the presence of a very thin layer of gelatinous material lying in the subcuta- 

 neous tissues. The latter presents a variety of colouring, being stained in 

 different portions of the area invaded by plaque in shades of yellow, green, and 

 red, the surrounding tissues presenting a normal appearance. On opening the 

 chest, the pleural cavities were found to contain 1,500 c.c. of blood-stained 

 fluid; free from flocculi. 



Lungs. Weight 15 Ibs. emphyeematous, tissues congested but not pete- 

 chiated. Pericardiat sac contains 800 c.c. of blood stained fluid. Heart 

 weighs 10 Ibs. 3 ozs. ; enlarged external surface presents healthy appearance. 

 On section walls of left ventricle hypertrophied, no subendocardial extravasa- 

 tions, firm blood clots in both the ventricles. Peritoneal cavity free from 

 fiuid. Liner weighs 17 Ibs , enlarged. On section tissues dark, yellowish-red in 

 colour and soft. Spleen weighs 6 Ibs. much enlarged, nearly three times normal 

 size. On section tissues dark, nearly black in colour and pulpy. Jidneys,-~ 

 R. 3 Ibs. 7 ozs., L. 3 Ibs., considerably enlarged. On section tissues pale and 

 hiluoo of each organ occupied by semigelatinous material. Stomach, normal in 

 appearance. Small intestines. On section m. m. vessels injected. Large 

 intestines in. in. congested. Bladder, urine contains colouring matter of blood 

 but no red blood corpuscles, on microscopical examination, m. m. somewhat 

 congested. 



