APPRNDTX. xxi 



Dourine mare on several occasions (trypanosoma never found in vaginal secro- 

 tion). Vendor did not exhibit any primary symptoms of the disease, but 18 days 

 after the first covering, a plaque made its appearance. From direct inocula- 

 tion of blood containing the trypanosomn, we are in a position to state that the 

 usual period is about 30 to 34 days and that 18 days is too short a period t 

 allow between inoculation of the b/cmatozoon and the appearance of the first 

 pliique. We must, therefore, negative the idea that Vendor had wholly 

 recovered after treatment and bad contracted Dourine a second time, and hold 

 that the trypanosoma remained in the system of the animal perhaps in a 

 mature form only rendered more or less innocuous by the prolonged administra- 

 tion of Mercury and Potass\uin Iodide,* but more, likely in an immature 

 form. It is evident that owing to the reduction in energy brought about from 

 the exertion in serving a mare on several occasions, a loss of power of resistance 

 was produced which allowed of the trypanosomata developing and thriving in 

 blood, which previously had been an unsatisfactory medium and had held 

 it in check. 



MONARCH. 



A bay Arab stallion, age 6 years, 14-1^ handi, was received at Babugarh 

 from Bombay, 2nd December 1902, and was cast for Cataract on March 29th 

 1903. 



The horso was received at the Bareilly Laboratory on the 31st March, and 

 a few days later, April 10th, was removed to the Imperial Bacteriological 

 Laboratory, Muktesar. 



May 4th, 1903. The animal'. was in good health and condition, and since its 

 arrival on April 13th, the morning and evening rectal temperatures have only 

 varied between 37 and 38C. On the mornings of the 4th, 6th, and 7th May 

 Monarch was allowed to cover mare III, the latter animal, as may be seen from 

 the notes of the case, was inoculated on the m. m. of the left labium, with a 

 slight trace of blood drawn from a cutaneous plaque on Kilngarth, on April 

 17th, eighteen days previously. At the time of covering, the mare exhibited 

 but slight symptoms of Dourine, the chief being some swelling of the left 

 labium of vulva and slight oedema of perineum, but there was no vaginal 

 discharge present. The vaginal mucus, however, was found to contain the 

 trypanosoma on microscopical examination. 



May 18th. The 6rst symptoms observed in Monarch were a few cracka 

 on the m. m. of the penis, superficial in character, which readily healed within 

 24 hours of their first appearance. Ten days later marked symptoms of colic 

 appeared, and these subsided within a few hours under appropriate treatment. 

 On June 3rd, thickening of the sheath became manifest for the first time and 

 was followed on the morning of the 6th by the eruption of three well marked 

 cutaneous plaquee, two on the left flank and the third on the right side of 

 the abdomen, these were all circular in form, pitted in the centre, varying 5n 



* Horse No. 89, Surra, recovered after the prolonged administration of arsenic 

 and when rcinocnlated with Surra trypabosoma 18 months later, ultimately suc- 

 cumbed to the disease, in a modified form. The hiumatozoon only appearing in 

 scanty numbers in tho circulation during the paroxysms which occurred. 



