APPKNDIT. XXXIX 



20th. -The condition of the animal remains unchanged and all symptoms 

 persist. Temp. A.M. 37'7 C, P. 42, H. 18 ; P M. 38-0 C., P. 62, U. 20. . 



21t. Disseminated urticarial eruptions have made their appearance over 

 both hip, left side of the chest, and on the right wither. All the oilier symp- 

 toms remain unchanged. Temp. A.M. 37-8 C., P. 52, E. 20; P.M. 3V9 C., 

 P. 60, R. 21. 



22nd. The animal was found this morning lying down, and when assisted 

 to rise was found to bo unable to maintain the erect position owing to weakness 

 across the quarters. The urticarial ernptions have generally dissappeared and 

 plaques Nos. 3, 26, and 27 have decreased in size and all other symptoms persist. 

 Temp. A.M. 37-9 C., P. 50, R. 16 ; P.M. S9'2 C., P. 62, R. 20. 



23rd. The animal maintains the recumbent position, but neverthelefs feeds 

 well. With the exception of the period during which the attack of colic was 

 present the appetite has never fallen off until yesterday morning ; the appetite, 

 however, returned later in the day and is now maintained. Plaque No. 3 ha* 

 disappeared during the past 24 hours and Nos. 26 and 27 have decreased in 

 size. The swelling and cadema of the vaginal m. m. has increased and extended 

 over the perineal region to the udder. 5 P.M. the animal is restlesa but feeds 

 well. The temperature has risen to 40'0 C. and the pulse and respirations 

 accordingly. Temp. A.M. 38'8 C., P. 40, R. 18 ; P.M. 40'0 C., P. 66, R. 32. 



24th. The animal after a restless night succumbed at 7-30 A.M. 



This mare was in season during almost the entire period between contract- 

 ing the disease and death. 



Only a clear watery fluid exuded at times from the vaginal m. m., and 

 although diligently searched for, the trjpanosoma was never discovered in the 

 secretion collected daily for microscopical examination. 



Trypanosomata were found in the blood of the plaques on numerous occa- 

 sions, but never in the blood of the general circulation of the animal. 



AUTOPSY, At 11 a.m. 24th September 1903. The skin was removed 

 carefully in order to observe whether any changes could be noted at the former 

 seats of plaques which had persisted for several days and then disappeared. 

 But no changes were found. At the time of death two plaques, Nos 26 and 27, 

 existed but were fading. On the removal of the skin from the right hide of the 

 neck where these plaques were situated, a thin film of gelatinous material 

 together with discolouration of the tissues at the seat of the patches respec* 

 tively, were all the signs noted. 



On opening the chest, no fluid was found in the pleural cavities. Lungs 

 deeply congested, apices almost black in colour and the Feats of .-light emphy- 

 sema. On section oedema of both organs. Pericardial toe contains only a 

 few cubic centimetres of an orange coloured fluid. Heart weighs 9 ft. 2 ozs. 

 enlarged. External surface yellowish red in colour, dotted over its surface are 

 minute dark red petechise. On tection the valves are stained a yellow colour, 

 but there are no subeudocardial extravasations. Muscle fatty. Liver weighs 

 18 ft. 10 ozs., enlarged, dark red in colour. On section the tissues are firm 

 and present a fairly healthy appearance. Spleen weighs 3 ft. 12 o/,-., nearly 

 twice the normal size. External surface of organ petechiated. On tection 

 tissues are somewhat softer than in normal condition and dark in colour. 



