xliv 



APPENDIX, 



30th August. The first and second plaques made their appearance on the 

 left flank and ribs respectively on the 116th day following the covering of the 

 mare, and it was not until the 3rd October (150fch day) that plaque No. 3 

 showed itself on the R. side of the chest. Prom this latter date up to the 31st 

 January, an interval of 120 days ; no further plaque had made its appearance. 



On examination of the animal with the exception of the following symp- 

 toms none could be found referable to Dourine. These were small leucodermic 

 patches on a somewhat thickened vulva, patency of the labia pudendi, slight 

 oedema of the vaginal m. m., an occasional appearance of oedema iu front of 

 the udder, and slight enlargement of the submaxillary and superficial inguinal 

 glands, which latter, however, were normal in consistency. 



The temperature of this animal has been recorded daily, morning and 

 evening, for ten months, during which period the maximum registered was 

 38'7 on one occasion only and the minimum 37*1 C. For days and weeks 

 together the recorded temperatures never rose to 33'0 or fell to 37'0 C. 



Points of interest. 



1. Presence of trypanosoma in vaginal mucus 34 days after covering. 



2. i, i> 84 days previous to eruption 

 of first plaque. 



3. Occurrence of paroxysms and intermissions of trypanosomata at irregular 

 intervals. 



4. Great increase in the number of trypanosomata in the vaginal mucus 

 following eruption of first and second plaques. 



6. Eruption of all three plaques during temporary absence of trypano- 

 gomata from vaginal mucus. 



6. Small number of plaques (3) which manifested themselves during tho 

 course of the disease. 



7. Symptoms mainly involving external genital organs. 



8. No symptoms indicative of nerve lesions. 



9. Two patches of leucoderma appeared on the vulva on 88th day after 

 covering. 



MAKE II. 



TABLE XVIII. 



Showing the number of plaques, their situation, dates of appearance and 

 disappearance, together with the duration, etc., of each respectively. 



