1 APPENDIX. 



5th. Plaques Nos. 10 (c), 14, and 17 have disappeared, Nos. 5, 6, 8, 19, 23, 

 and 25 have decreased, Nos. 20, 21, and 22 persist, while No. 24 has become 

 raised and more prominent. The swelling of the vulva has decreased, but the 

 oedema and vaginal petechise have remained stationary. During the time the 

 evening temperature was being taken the animal allowed all the weight of the 

 body to be more or less supported by the off hind limb. Temp. A.M. 38'6 C., 

 P. 40, R. 16 ; P.M. 38-9 C., P. 44, K. 20. 



6th. Plaque No. 22 has increased in size 1*5 inches in diameter, Nos. 6, 19, 

 and 21 have decreased, while Nos. 5, 8, 20, 23, and 24 remain as before. 

 The swelling and oedema of the external genital organs has enormously increased, 

 extending over the perinseum and partially involving the udder. The 

 vaginal petechise are fading (photograph). Temp. A.M.39'0 C., P. 42, E. 16 ; 

 P.M. 39-4 C., P. 44, R. 18. 



?th. Plaque No. 6 has disappeared. Nos. 5, 8, 19, and 22 have decreased, 

 while Nos. 20, 21, and 23 have remained stationary. Plaque No. 24 has 

 increased to 2'5 inches in diameter. The swelling and oedema involving the 

 perinseum, etc-, has increased during the past 24 hours. Temp. A M. 37'3 C. 

 P. 36, R. 16 ; P.M. 38-4 C., P. 38, E. 20. 



8th. Plaques Nos. 5, 8, 19, 22, and 24 have decreased in size. No. 20 has 

 increased and now measures 2 inches in diameter and No. 21 2'5 inches in dia- 

 meter, No. 23 persists. The swelling and oadema of the external genitals has 

 decreased. Temp. A.M. 37'4 C., P. 38, R. 14 ; P.M. 38'1 C., P. 43, E. 22. 



9th. Plaque No. 22 has disappeared, and Nos. 5 and 8 have decreased in 

 size. Nos. 20 and 21 are more prominent, the latter measuring 2'26 in dia- 

 meter, while Nos. 19, 23, and 24 have remained stationary. The swelling and 

 oedema of the external genitals and permeeum is steadily decreasing. Temp. 

 A.M. 37-6 C., P. 40, E. 16 ; P.M. 38'1 C., P. 36, R. 30. 



10th. Plaques Nos. 5 and 24 have disappeared and Nos. 8 and 19 have 

 decreased in size. Plaque No. 1 has appeared a third time and is now raised 

 and has a diameter \\ inches. Nos. 20, 23, and 25 have increased in size, the 

 first and last measuring 1'5 and 2'5 inches in diameter respectively. The swell- 

 ing and oedema have disappeared from the perinmim, but the enlargement of 

 the external genitals persists. Temp. A.M. 37'6 C., P. 40, K. 12 ; P.M. 37'9 C., 

 P. 40, R. 18. 



llth. Plaque No. 19 has disappeared. Nos. 1 and 20 have increased in size, 

 the former measuring 2"x l" and the latter 2 inches in diameter, well raised 

 and soft ; swelling of labia persists. The'animal drags both hind limbs when 

 walking. Temp. A.M. 37'6 C., P. 36, R. 14 ; P.M. 38-0 C., P. 42, R. 14. 



12th> Plaque No. 1, which appeared for the third time, has increased and 

 how measures 3"x 1*75'' and is well raised above the surrounding skin. Swell- 

 ing of labia persists. Temp. A.M. 37'4 C., P. 38, R. 18 ; P.M. 37'3 C., 

 P. 88, R. 17. 



13th. Plaque No. 8 has decreased in size, but Nos. 1, 20, 23, and 25 have 

 remained stationary. Swelling decreased. Temp. A.M. 37*4 C., P. 30, R. 16 j 

 P.M. 38-1 C., P. 40, R. 16. 



14th. During the night plaques Nos. ]5 and 16 reappeared, the bonders 

 of which are slightly raised 5 No. 8 disappeared ; NOB. 1 and 23 increased in 



