1XX1V APPENDIX. 



MARE VI, 



Country-bred mare covered by Arab stallion Monarch, the subject of 

 Dourine (during early period of eruption of cutaneous manifestations, 

 but absence of sores from penis) No vesicles or other eruption implicating 

 vulva or vaginal m. in. first flaque appeared on 31st day following pri- 

 mary covering (trypanosoma) followed at irregular intervals by successive 

 crops of plaques which involved the skin of the body and neck principally. 

 Thickening of labia pudendi, followed by oedema of udder and later by 

 cedema on under- surf ace of abdomen Stiffness of the right hind limb. 

 Absence of leucodermic patches implicating tissues of vulva, anus and 

 udder, as also of nervous symptoms up to the 235th day after covering. 



A bay country-bred mare 13-f hands, aged 6 years, Sire Finale, was cast 

 from the Government Remount Depot, Hapur, on the 21st May 1903. The 

 animal was received at the Laboratory, Muktesar, on the 25th May 1903. 



The mare during a period of oestrum was covered on June llth, 1903, and 

 on several occasions during the next few days, by an Arab Horse, Monarch 

 suffering from Dourine, (experimentally contracted) during, the earjy stage of 

 eruption of cutaneous plaques, but the penis was free from sores or eruption of 

 any kind. 



No vesicles or ulcers involving the vaginal m. m. or vulva followed the 

 unions. On the llth July, the 31st day following the primary covering, three 

 plaques made their appearance between 6 A.M. and noon, involving the skin of 

 the right side of the neck, flank and hip, followed later in the day by a fourth 

 situated on the left side of the neck. The trypanosoma was searched for and 

 discovered in the blood drawn from three of the plaques examined. Between the 

 llth July 1903 and the 8th January 1904, a period of 181 days, 75 plaques 

 made their appearance at irregular intervals, on the skin of the neck, body, and 

 hind quarters, leaving the cutaneous surfaces of the limbs unaffected. The 

 plaques appeared singly, in pairs or in numbers iip to eight within 24 hours, 

 the interval between the appearance of the successive crops of plaques varying in 

 length from one to thirty days. 



During the interval between the llth June 1903 and January 31st, 1904, 

 but few symptoms other than those before mentioned were observed. The 

 following, however, require special notice. On the 12th July 1903, the day 

 following the eruption of the first cutaneous manifestation?, the inferior 

 commissure of the vulva became enlarged and cedematous ; three days later, 

 15th, the left labium became increased in size, and on the 19th both labia were 

 equally thickened. By the 4th August, the vulva became pendulous from 

 the amount of cedematous swelling present. By the morning of August 10th 

 all the swelling had subsided, the cedema had become absorbed and the vulva 

 presented its normal condition. 



Swelling and cedema of the udder was noted on the 27th July, and after 

 persisting for several days became absorbed on the same date (August 10th) 

 as that involving the vulva. The former did not subsequently recur. 



Later, 10th October, cedema made its appearance on the under-surface of 

 the abdomen, spreading forward ; after increasing and diminishing in amount 



