APPENDIX. 



MARE VIII. 



Country-bred mare covered by Arab stallion Monarch, the subject of 

 recent Dourine. Appearance of Vesicular Exanthema (coital), later 

 followed by leucoderma of the external affected parts Eruption of Jint 

 cutaneous plaque on thirty-third day after covering (Irypanototna dii* 

 covered) followed during ensuing three and half months by eighteen 

 similar patches Vaginal mucus contained trypanosomata in large 

 numbers on the 17th day, and at varying intervals up to 4 months after 

 eruption of last plaque Absence of cerebre-spinal complications up to 

 212th day after covering. 



A country-bred mare, Sire unknown, foaled 1st March 1900, 14-3.J, was cast 

 from the Government Uemount Depot, Hapur (No. 4268), on May 21st, and 

 was received at Muktesar on the 20th May 1903. 



This mare was covered by the Arab stallion Monarch at noon on July 6th, 

 1903. At the time of serving numerous small ulcers existed en the free por- 

 tion of the penis. 



On the morning of July 6th, 19 hours after covering, vesicles had already 

 appeared on the inner surface of the labia pudendi and on the vaginal mucous 

 membrane. On the 7th and 8th, the vaginal m. m. presented a deep red colour 

 and numerous small ulcers existed over its surface and a muco-purulent dis- 

 charge escaped from the passage. On the 9th, a second series of symptoms 

 appeared complicating the vulva and tissues situated externally. These are 

 described separately. From the 9th to the 17th inclusive, the vaginal symptoms 

 increased in severity, and between the ISth and 20th some of the ulcers on the 

 m. m. healed. On the 21st, the trypanosoma was observed for the first time in 

 the vaginal mucus, the muco-purulent discharge was now intermittent in its 

 appearance, for the most part being only observed in the morning and evening. 

 Twenty-four hours later petechise appeared on the m. m. and persisted for 

 several days ; they then faded and finally disappeared on tho 23rd, and by the 

 morning of the 26th all ulcers on the m. m. had healed. 



The external manifestations above referred to were first observed on the 

 morning of the 9th, when vesicles and pustules raised above the surface of the 

 surrounding tissues, both discrete and confluent, were found on the vulva and 

 tissues surrounding that part. During the next 48 hours fresh vesicles and 

 pustules formed, while the ones which previously existed developed into ulcers 

 and from 12th to the 15th the evolutionary process continued, some ulcers 

 healing while fresh ones formed. During the 16th and 17th, the condition 

 appeared to remain stationary, but from this latter date healing proceeded with- 

 out interruption. 



On the 31st July, the vulva became thickened and generally enlarged, and 

 on the following day numerous black film-like scales became denuded, leaving 

 eight patches of leucoderma. The thickened condition of the labia pudendi 

 persisted until the 2nd September when it subsided, but was followed on the 3rd 

 by an ocdematous swelling'on either side of tho vulva which persisted until the 

 Uth September, and by a further patch of leucoderma, the ninth in order of 

 sequence which implicated the tissues of the anus. 



