118 INFLAMMATION. 



grated or dissolved and absorbed or otherwise disposed of by phagocytes. 

 The tissue may become soaked and swollen by the transuded serum, and 

 the connective-tissue cells in the vicinity may undergo proliferative or 

 degenerative changes. 



Granulation Tissue. After a variable time, usually on the second or 

 third day if all goes well, the surfaces of the wound may be more or less 

 covered with tiny red nodules called granulations. These granulations 

 contain numerous thin-walled blood-vessels which have sprouted out 

 from the old vessels near the seat of injury, and around these a new 

 loose, succulent tissue is formed, largely, it is believed, from prolifer- 

 ation of connective -tissue cells. This is called granulation tissue (Fig. 

 46). On the surfaces of the granulations are usually pus cells in vary- 



FIG. 47. GRANULATION TISSUE FROM WOUND OF SKIN. 

 The walls of the blood-vessels are thicker and intercellular fibrils are forming. 



ing quantity, or the granulations may be more or less covered with 

 dried exudate. The way in which the new blood-vessels form by proto- 

 plasmic sprouts from the old, and the manner in which connective 

 tissue develops from older couuectiA'e-tissue cells have been already de- 

 scribed in the section on Eegeneration. Let it suffice here to say that 

 the cells of the granulation tissue are at first mostly small and spher- 

 oidal or polyhedral, and are usually packed closely together with only a 

 small amount of fluid intercellular substance. Presently some of the 

 cells become larger and polyhedral, elongated, fusiform, or branched, 

 and after a while 'a delicate, fibrillar intercellular substance makes its 

 appearance about them and grows more and more abundant (Fig. 47). 

 These larger, variously shaped cells, which appear to be formed out of 

 the small spheroidal or indifferent cells of the granulation tissue, are 

 usually granular, and the nucleus is generally large and distinct. Some 

 of these larger cells which seem to be more or less directly concerned in 

 the formation of intercellular fibres are called fibroblaftts (Fig. 48). 



