254 



THE INFECTIOUS DISEASES. 



filtration may be formed. There may be an excessive production and exfoliation of 

 epidermis over the infiltrated area, or an ulceration of the new tissue. 



Microscopical examination shows the lesion to consist of small spheroidal cells in- 

 termingled with variable numbers of larger, polyhedral cells and cell masses, and in 

 many cases giant cells (Fig. 125). In some cases a well-marked reticulum is present 

 between the new cells, and these are often grouped in masses around the blood-vessels. 

 In some cases there is, without previous ulceration, a formation of new connective tis- 

 sue in the diseased area, and a well-marked cicatrization ; in other cases the cells and 

 intercellular substance undergo a disintegration which leads to ulceration. Tubercle 

 bacilli in small numbers may be found in these lesions. In the clinical group of diseases 

 called lupus there are other forms of lesion which are not incited by the tubercle 

 bacillus. 



Bibliography of Tuberculosis. 



The announcement of the discovery of the bacillus tuberculosis by Koch was made 

 in the Berliner klin. Wochenschrift, 1882, No. 15. A most elaborate and valuable article 

 on the same subject by Koch is contained in the " Mittheilungen aus dem Kaiserlichen 

 Gesundheitsamte," vol. ii. 



The abundant literature on the subject of the tubercle bacillus which has accumu- 

 lated since 1882 is for the most part scattered througli the German, English, and French 

 journals. 



An excellent critical resume of the subject by Lartigau, with selected bibliography, 

 may be found in the "Twentieth Century Practice," vol. xx. 



FIG. 125. LUPUS OF FACE. 



In the large work of Straus, "La Tuberculose, " 1895, the experimental aspects of 

 the subject are fully considered. 



In the work of Cornet, "Die Tuberculose," 1899, together with the general and 

 clinical consideration of the disease, the modes of infection and prophylaxis are set 

 forth, with bibliography. See also Cornel and Meyer, Kolle and Wassermann's " Hand- 

 buch der Mikroorganismen," Bd. ii., p. 78, 1902. 



