596 THE LIVER. 



iiew tissue is most commonly formed and most abundant in the periph- 

 ery of the lobules along the so-called capsule of Glissou, but it may ex- 

 tend into the lobules between the liver cells. It may surround single 

 lobules, or more frequently larger and smaller groups of lobules (Fig. 



aBB ft 



FIG. 361. CHROXIC INTERSTITIAL HKPATITIS CIRRHOSIS. 

 o. New-formed connective tissue ; 7j, dilated blood-vessels of the new tissue ; c, gall duct. 



361). It may occur in broad or narrow, irregular streaks or bands. 

 It is frequently more abundant in one part of the liver than in another. 

 The new-formed tissue tends to contract, and thus compromise by press- 

 ure the enclosed islets of liver tissue, causing them to project, in larger 

 and smaller nodules, from the surface of the organ. The liver cells may 

 be flattened or atrophied from pressure ; or, from interference with the 

 portal circulation, they may atrophy or become fatty ; or they may be- 

 come colored with bile pigment. This form of lesion is called atrophic 

 cirrhosis. 



The varied appearances which cirrhotic livers present to the naked 

 eye depend largely upon the amount and distribution of the new con- 

 nective tissue and upon the secondary changes in the liver cells. The 

 surface may be very rough and uneven from the projection of larger 

 and smaller irregular-shaped nodules of liver tissue (Fig. 362) be- 

 tween which are the depressed contracted bands of new-formed con- 

 nective tissue. On the other hand, the surface of the liver may 

 be smooth, when the new connective-tissue bauds are small, evenly 

 distributed or little contracted. Again the liver may be greatly 

 distorted and misshapen by the atrophy of the parenchyma and the 

 contraction of large and irregular bauds or masses of new con- 

 nective tissue. In section through cirrhotic livers the new tissue may 



