56 BACTERIAL POISONS 



the number of the parasites, could hardly be accounted for in any 

 other way, while the mere destruction of the red cells itself could be 

 explained by the manifest proteolytic activity of the parasite and 

 consequent changes in the osmotic tension of the cell. In trypanoso- 

 miasis the late symptoms at least (sleeping sickness) would suggest 

 a toxic cause, and in relapsing fever the entire symptom complex 

 is toxic in character. As I have said, however, we have no definite 

 knowledge on the subject, which is, no doubt, owing to the fact that 

 until quite recently we were unable to cultivate the parasites in 

 question as we would bacteria, and could hence not study the products 

 of either their growth or disintegration. 



BIBLIOGRAPHY. 



Brieger. Die Ptomaine, Berlin, 1885 und 1886. 



Vaughan and Novy. Toxins, Ptomains, Leucomains, etc., Philadelphia, Lea 

 Bros. & Co., 1902. 



Park, W. H. and Williams, A. W. The Production of Diphtheria Toxin, Jour. 

 Exp. Med., 1896, i, 164. 



Ehrlich, P. Ueber die Konstitution d. Diphtheriegiftes, Deutsch. med. Woch. 

 1898, xxiv, 597. 



Behring, E. Ueber Infektionsgifte, Deutsch. med. Woch., 1898, No. 36, 565. 



v. Ermengem. Der Bazillus botulinus u. d. Botulismus, Kolle u. Wasser- 

 mann's Handbuch d. pathogenen Microorganismen, 1912, iv. 



Ornstein, O. Ein Fall v. Botulismus, Zeit. f. Chemotherap, 1913, i, Orig. 458. 



Aronson, H. Konstitution d. Toxine, Ehrlich Festschrift, Jena, 1914, 166. 



Pfeiffer, R. Untersuchungen tiber d. Choleragift, Zeit. f. Hyg., 1892, xi, 373. 



Pfeiffer, R. Ueber Bakterien-Endotoxine u. ihre Antikorper, Jahresb. iiber 

 d. Ergeb. d. Immunitatsforsch., 1910, vi, Abth. 1, 13. 



Cole, R. Toxic Substances Produced bv the Pneumococcus, Jour. Exp. Med., 

 1912, xvi, 644. 



Fukuhara, Y., and Auds, J. Ueber d. Bakteriengifte, insbesondere d. Bakter- 

 ienleibergifte, Zeit. f. Imm., 1913, xviii, 350. 



Zinsser, H. On Anaphylatoxins and Endotoxins of the Typhoid Bacillus, 

 Jour. Exp. Med., 1913, xvii, 117. 



Buchner. On Bacterial Proteins, Munch, med. Woch., 1897. 



Friedberger, E., u. Ito, T. Beitrage zur Pathogenese d. Fiebers, Zeit. f. Imm., 

 1912, xv, 303. 



Friedberger, E., Goldschmid, E., Szymanowski, Z., Schiitze, A., u. Nathan, 

 E. Beitrage zur Frage d. Bildung d. Anaphylatoxin aus Mikroorganismen, Zeit. 

 f. Imm., 1911, ix, 359. 



Seitz, A. Ueber Bakterienanaphylaxie, Zeit. f. Imm., 1912, xiv, 91. 



Dold, H., u. Aoki, K. Weitere Studien iiber d. Bakterienanaphylatoxin, 

 Zeit. f. Imm., 1912, xv, 171. 



Schittenhelm, A., u. Weichardt, W. Studien tiber d. biologische Wirkung 

 bestimmter parenteral einverleibter Eiweissspaltprodukte, Zeit. f. Imm., 1912, 

 xiv, 609. 



Lura, A. Ein Beitrag z. Mechanismus d. Anaphylatoxinbildung aus Bak- 

 terien, Zeit. f. Imm., 1912, xii, 701. 



Dold, H., u. Aoki, K. Ueber d. Bildung v. Anaphylatoxin aus verschiedenen 

 Mikroorganismen, Zeit. f. Imm., 1912, xiii, 200. 



De Waele, H. Le role des acides amines dans I'intoxication proteinique, Zeit. 

 f. Imm., 1912, xiii, 605. 



