FORMATION OF ANTIBODIES 129 



Coefficient of distribution Threshold of action ex- 



Narcotio = Concentration in fat pressed in fractions of 



Concentration in water. the normal solutions. 



Trional 4.46 0.0018 



Tetronal 4.04 0.0013 



Butylchoralhydrate 1.59 0.002 



Sulfonal 1.11 0.006 



Bromal hydrate 0.66 0.002 



Triacetin 1.30 0.01 



Diacetin 0.23 0.015 



Chloralhydrate 0.22 0.02 



Ethylurethane .0.14 0.04 



Monacetin . . . .. . . . 0.06 0.05 



Methylurethane 0.04 0.4 



In accord with this view regarding the action of the majority of 

 the chemical poisons upon the cells of the body is also the fact 

 that these substances can again be extracted from the cells by the 

 use of appropriate solvents, which, of course, would not be possible 

 if chemical union had taken place. 



We may thus sum up by saying that only those substances can / 

 possess antigenic properties which are capable of entering into vS 

 chemical union with the cells, but that in addition a special "Bil- 

 dungsreiz" must be exercised upon the cell which is peculiar to 

 the antigens. 



BIBLIOGRAPHY. 



Ehrlich, P. Die Schutzstoffe d. Blutes, Deutsch. med. Woch., 1901. 



Discussion to Gruber's Lecture: Zur Theorie d. Antikorper, Wien. klin . 

 Woch., 1901, pp. 1190, 1214, 1244, 1272. 



Discussion to Ehrlich's Lecture: Die Seitenkettentheorie u. ihre Gegner, 

 Deut. med. Woch., 1902, Vereinsbeilage, No. 3, p. 17. 



Aschoff, L. Ehrlich's Seitenkettentheorie, Zeitsch. f. allgem. Physiologic, 

 1902, i, Heft. 3. 



v. Dungern. Rezeptorenspecifitat, Ehrlich-Festschrift, Jena, 1914, p. 162. 



Wassermann, A. Die Seitenkettentheorie, Ehrlich-Festschrift, 1914, p. 134. 



Madsen, R. Methodik und quantitative Prinzipien b. d. Behandlung d. 

 Immunitatsprobleme, Ehrlich-Festschrift, Jena, 1914, p. 151. 



Halpern, J. Experimentelle Studien iiber Antikorperbildung, Zcit. f. Imm., 

 1911, xi, 609. 



