176 ANAPHYLAXIS IN ITS RELATION TO DISEASE 



interesting to note that a number of persons who experienced a 

 severe anaphylactic attack immediately following the injection of 

 horse serum were also affected by the exhalation from the horses. All 

 such cases are unquestionably anaphylactic in character and refer- 

 able to the absorption of organic matter that is present in the ema- 

 nations from animals and human beings. This explanation seems 

 reasonable in view of certain findings reported by Weichardt. This 

 observer noted that guinea-pigs which had been injected with fluid 

 through which the expired air of human beings had been passed 

 were thus rendered anaphylactic to human bronchial secretion, and 

 on intravenous injection with the latter responded with a marked 

 drop in temperature and sopor. 



Especially instructive also are those cases in which the ingestion 

 of such common articles of food as egg albumen and cows' milk is 

 followed by most abnormal consequences. Landmann thus records 

 a case where the ingestion of a bit of egg albumen, no larger than a 

 pea, was followed after a quarter of an hour by a burning sensation 

 and swelling of the tongue, intense edema of the palate and pharynx, 

 salivation, lacrimation, burning and itching in the Eustachian 

 tubes, vomiting, severe diarrhea, and great prostration, while its 

 application to the skin resulted in urticaria. Such findings are quite 

 analogous to the anaphylactic enteritis which may be observed on 

 injecting sensitized dogs with egg albumen, and where postmortem 

 the mucosa and submucosa of the entire intestinal tract inclusive 

 of the pylorus is studded with miliary hemorrhages. 



In a case of so-called fagopyrismus (buckwheat poisoning), which 

 unquestionably also belongs to this order, Thayer had the patient 

 vaccinated with the substance in question, the result within half 

 an hour being a feeling of oppression and nausea, frequent cough, 

 a rapid and intermittent pulse, suffusion of the conjunctive, ery- 

 thema, intense pruritus, and local urticaria at the point of injection. 



In a case of antipork idiosyncrasy, Bruck injected some of the 

 patient 's serum into a guinea-pig and followed this up with an injec- 

 tion of hog serum, the result being a typical anaphylactic shock, 

 while the control animals showed no symptoms whatever. 



Quite recently the same writer has further shown that the curious 

 hypersusceptibility which certain persons show toward iodoform can 

 be passively transferred in the individual's serum to guinea-pigs, 

 and Klausner could demonstrate that this was possible even after 



