CHEMOTHERAPY IN MALIGNANT DISEASE 293 



be due to the liberation and action of these very substances. They 

 accordingly studied the effect of various cholin preparations upon 

 tumor growth, and found as a matter of fact that the changes 

 resulting in the tumors were perfectly analogous to those produced 

 by ray treatment. Since cholin could be shown to possess a high 

 pow r er of diffusion the thought then suggested itself, in view of the 

 observations above related concerning the selective action of colloidal 

 metals upon tumor cells, to use the cholin as carrier of these metals. 

 Studies in this direction showed that beneficial effects may indeed 

 be thus achieved in the animal experiment with colloidal selenium, 

 copper, cobalt, iron, zinc, and arsenic, when dissolved in cholin 

 solutions, and that this could be accentuated by combining a metal 

 of high electrical tension with one of low tension, or even with one 

 which in itself is inactive, such as selenium-vanadium, selenium-cobalt, 

 copper-cobalt, etc. There is thus still another avenue for attack, 

 and one which likewise seems to promise profitable results. 



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