THE PROBLEM 



ONE of the mysteries of the human race is the fact that 

 civilized man is subject to certain diseases that rarely 

 attack primitive man and never appear in wild and domestic 

 animals. These are various nervous and mental disorders, 

 exophthalmic goiter, neurocirculatory asthenia,- Raynaud's 

 disease, diabetes, peptic ulcer, essential hypertension, and 

 coronary disease. Each of these diseases is related to the 

 expenditure of energy. It would appear that this fact alone 

 offers a biological cue to the mechanism of the energy 

 characteristics of man and animals. 



It is well known that only certain organs and tissues con- 

 trol the expenditure of energy in all animals, including man. 

 These are the brain, the heart and the blood, the thyroid 

 gland, the adrenal glands, the celiac ganglia, and the 

 sympathetic system. 



I postulated that if we were to analyze, measure, and 

 compare the organs of this energy-controlling system in 

 fish, reptiles, birds and mammals and then compare the 

 influence of the heat of the tropics and the cold of the arctic 

 upon the size of these organs heat and cold and struggle 

 and survival being the most potent of all environmental in- 

 fluences we should be able to account for the varying 

 intelligence, power, and personality among the different 

 species of animals and the races of man. We should be able 

 to find for man an energy formula distinct from that for 

 wild and domestic animals and, further, an energy formula 

 for civilized man. This became our quest. 



THE QUEST 



While Mrs. Crile and I were hunting in Africa in 1927, 

 two phenomena well known to hunters of big game excited 

 our attention. 



The first was that an antelope, a lion, or any high- 



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