RHAMNUS PURSHIANA 265 



interest concerning it remains yet unwritten. To this 

 writer its journey from the aborigines to scientific use 

 and systematic therapeutic study appears to parallel 

 the course of such drugs as coca, jalap, benzoin, sassa- 

 fras, cinchona and Croton Tiglium. 



A descriptive treatise, recording some previously un- 

 written phases of the dramatic history of rhamnus, 

 familiar only to those concerned in its introduction, 

 was contributed by this writer, 1 in 1896, to the Research 

 Committee of the American Pharmaceutical Associa- 

 tion. From this we take the following brief summary: 



"In a paper contributed to New Preparations? Octo- 

 ber 15, 1877, p. 8, the late Dr. J. H. Bundy, of Colusa, 

 California, commended 'Cascara Sagrada' as a val- 

 uable remedy in the treatment of constipation. This 

 notice was by means of a brief note that was part of a 

 paper on Berberis aquifolium, Dr. Bundy promising, 

 however, to give the subject further attention later. 

 Dr. Bundy says: 



"It is not my purpose to treat on Cascara Sagrada 

 in this paper, but using it in connection with the Ber- 

 beris, I simply make mention of it. In the future I will 

 introduce the drug to the profession." 



This, so far as the writer can determine, was the first 

 reference concerning this remedy in pharmaceutical or 

 medical print. Agreeably to promise, in January, 1878, 

 Dr. Bundy contributed to New Preparations a paper on 

 "Cascara Sagrada," in which he gave the uses of the 

 fluid extract of that remedy. Following this came many 

 papers from Dr. Bundy and other physicians, twenty 

 contributions on the subject being printed in New 



1 Introductory to'a contribution from chemical investigations of Rhamnus Purshiana, 

 undertaken by Alfred R. L. Dohme (175a). 



' New Preparations, Detroit, Mich. Parke, Davia & Co. (467). 



