638 APPENDIX B. 



number of cell-generations possible for the cells of each organ and tissue." 

 (p. 28) 



" The above-mentioned considerations show us that the degree of repro- 

 ductive activity present in the tissues is regulated by internal pauses while the 

 natural death of an organism is the termination the hereditary limitation 

 of the process of cell-division, which began in the segmentation of the ovum." 

 (p. 30) 



Now, though, in the above extracts there is mention of " in- 

 ternal causes " determining " the degree of reproductive activity " 

 of tissue cells, and though, on page 28, the "causes of the loss" 

 of the power of unlimited cell-production " must be sought out- 

 side the organism, that is to say, in the external conditions of 

 life," yet the doctrine is that somatic cells have become consti- 

 tutionally unfitted for continued cell-multiplication. 



" The somatic cells have lost this power to a gradually increasing extent, so 

 that at length they became restricted to a fixed, though perhaps very large, 

 number of cell-generations." (p. 28) 



Examination will soon disclose good reasons for denying this in- 

 herent restriction. We will look at the various causes which 

 affect their multiplication, and usually put a stop to increase after 

 a certain point is reached. 



There is first the amount of vital capital given by the parent ; 

 partly in the shape of a more or less developed structure, and 

 partly in the shape of bequeathed nutriment. Where this vital 

 capital is small, and the young creature, forthwith obliged to 

 carry on physiological business for itself, has to expend effort in 

 obtaining materials for daily consumption as well as for growth, 

 a rigid restraint is put on that cell-multiplication required for a 

 large size. Clearly, the young elephant, starting with a big and 

 well-organized body, and supplied gratis with milk during early 

 stages of growth, can begin physiological business on his own 

 account on a great scale ; and by its large transactions his system 

 is enabled to supply nutriment to its multiplying somatic cells 

 until they have formed a vast aggregate an aggregate such as 

 it is impossible for a young mouse to reach, obliged as it is to 

 begin physiological business in a small way. Then there is the 

 character of the food in respect of its digestibility and its nutri- 

 tiveness. Here, that which the creature takes in requires much 

 grinding-up, or, when duly prepared, contains but a small amount 

 of available matter in comparison with the matter that has to be 

 thrown away ; while there, the prey seized is almost pure nutri- 

 ment, and requires but little trituration. Hence, in some cases, 

 an unprofitable physiological business, and in other cases a profit- 

 able one ; resulting in small or large supplies to the multiplying 

 somatic cells. Further, there has to be noted the grade of 

 visceral development, which, if low, yields only crude nutriment 

 slowly distributed, but which, if high, serves by its good appli- 



