FOREWORD 23 



To be sure, our knowledge of this new science of Non-specific 

 Protein Therapy is only in its rudiments. Prior to the appear- 

 ance of my paper of October, 1914, the principles upon which 

 it is based had not been explicitly formulated. Prior to October 

 2, 1915, no comprehensive statement of the therapeutic possibili- 

 ties of the method had been published. Prior to July, 1916, no 

 conclusive demonstration of the Protein principle, as such, had 

 been made. And the first elaborate formulation of the micro- 

 scopical evidence in support of the earlier inferences was pub- 

 lished as recently as December 1, 1916. Meantime a collocation 

 of the entire evidence available up to date, reproducing in full 

 the original formulation of the Proteomorphic Theory itself, 

 with sundry amplifications, and detailing the applications of the 

 method throughout the wide domain of disturbed protein meta- 

 bolism, is given for the first time in the present work, in com- 

 bination with the second edition of the Monograph on The Pro- 

 teal Treatment of Cancer and Allied Conditions, announced for 

 issue early in April, 1918. 



Notwithstanding the newness of the subject, however, Proteal 

 therapy has passed far beyond the experimental stage. Much 

 remains to be learned, of course, but much that is definite and 

 tangible is already precisely known. I have personally adminis- 

 tered many hundreds of doses of the various Proteals to patients 

 suffering from a wide range of maladies, from simple asthenias 

 and anaemias to pernicious anaemia, intestinal toxaemia, lymphatic 

 leukaemia, arteriosclerosis, rheumatoid arthritis, goitre, cancer, 

 and tuberculosis. My direct, personal office and bedside observa- 

 tion of patients under Proteal treatment comprises not far from 

 five hundred cases. I have been professionally consulted by 

 fellow-physicians and have advised with reference to the Pro- 

 teal treatment of about two thousand additional cases. My office 

 files contain more than six thousand letters dealing directly with 

 the subject, received (and I may add, without exception, promptly 

 answered) within the past two and a half years. My original 

 blood-examination records number not far from twelve hundred. 



Meantime more than fourteen thousand ampules of the various 

 Proteals have been sent out from my private laboratory to co- 

 operating members of the profession within the past year, and 

 reports from these physicians give invaluable clues to the appli- 

 cations and limitations of the method. 



The deductions from this substantial experience, including a 

 full elaboration of my hematological discoveries, constituting the 

 first comprehensive study of the Theory and Practice of Proteal 

 Therapy, appear in the present book. 



Here, and in the Monograph so frequently cited, I have at- 

 tempted to justify by evidence my belief that the non-specific 



