FOREWORD 



This book is essentially a Monograph detailing the author's 

 personal discoveries, original theories, and practical experiences 

 in a new domain of therapeutics. 



It presents a series of new observations and certain novel 

 theories of which it may unqualifiedly be affirmed that they are 

 important if valid. 



As a matter of course, not all these series of new observations 

 and theories are on the same plane, either of importance, of orig- 

 inality, or of verisimilitude. It will be "well, therefore, to give 

 a preliminary outline of both theories and practical discoveries, 

 with suggestions as to their relative importance in the estimate 

 of the author. Such an outline will be of value to the reader, 

 both in his preliminary appraisal of the matter presented and 

 in orienting his detailed study of the evidence as given in the text. 



First of all, as constituting the most general analysis, I would 

 point out that three fundamental new discoveries are conceived 

 to be represented. These are : 



(1) A physiological discovery, to the effect that (a) the 

 mononuclear leucocytes are the agents vitally concerned in begin- 

 ning hydrolysis, and (b) the red corpuscles the agents concerned 

 with the completion of decompounding of foreign proteins in the 

 parenteral system. This is the essence of the Proteomorphic 

 theory. 



(2) The therapeutic discovery that foreign proteins and pro- 

 tein by-products introduced hypodermically into the parenteral 

 system constitute antigens that stimulate responsive activities of 

 the organism of such character as to aid tremendously in the fight 

 of the organism against the evil effect of other foreign proteins 

 of whatever character, introduced by pathological processes, in- 

 cluding (a) the proteins associated with the bodies of pathogenic 

 bacteria, (b) heterologous protein products associated with de- 

 fective digestion and assimilation, and (c) autologous proteins 

 associated with the hyperplasia of various organs, including the 

 so-called malignant neoplasms. This conception, in itself an 

 application of the Proteomorphic principle, furnishes the founda- 

 tion for Non-specific Protein Therapy in general and Proteal 

 Therapy in particular. 



(3) The discovery that a single protein or combination of pro- 

 teins used therapeutically cannot usually produce optimum re- 

 sults, because the system becomes sated or immunized and no 



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