THE SCIENCE AND ART OF PROTEAL THERAPY 139 



cation in the number of neutrophiles and small lymphocytes from 

 the initial dose of the vegetable protein. A question not unnat- 

 urally arises as to whether there is any mutual relation between 

 the two groups of leucocytes, or whether the modification of their 

 numbers has been brought about independently. Glancing at the 

 first chart, one might think that there must be some mutual rela- 

 tion, inasmuch as the lines showing modification of the neutro- 

 philes run almost parallel with those showing modification of the 

 small lymphocytes. But in the second chart, we find that the 

 slope of the line is reversed, the neutrophiles showing a rapid rise 

 after the first dose and the lymphocytes a rapid decline. 



It is not impossible to frame a theory that would harmonize 

 these seemingly contradictory results, but perhaps it is not worth 

 while to attempt to do so at the moment. Our chief present con- 

 cern is with the observed facts, which fortunately are unequiv- 

 ocal. As above outlined, these include a notable departure from 

 the normal blood picture brought about by the administration of 

 the protein remedies as evidenced in a relatively enormous in- 

 crease of the larger monocytes, a conspicuous increase of the 

 eosinophiles and basophiles ; and a tendency to bring the small 

 lymphocytes and the neutrophiles within normal bounds. 



By way of recapitulation, it is well to recall that Vaughan's 

 experiment seems to show that the specific enzymes of the large 

 mononuclears have particular value in proteolyzing the cancer 

 proteins. Stated otherwise, the large mononuclears would seem 

 to have particular affinity for cancer proteins ; which is only an- 

 other way of saying, probably, that they are particularly adapted 

 to deal with proteins of an embryonic type. The fact that the 

 large mononuclears abound relatively in the normal blood of the 

 child may be recalled in this connection. 



BLOOD CHANGES IN TUBERCULOSIS 



Many instances of spectacular changes in the corpuscular rela- 

 tions under Proteal treatment are given in the cancer Mono- 

 graph. Here it is desirable to supplement these records by 

 citing a few cases representing maladies of different types. 



Here, for example, is the case of J. G., a patient in the late 

 stages of tuberculosis of the lungs. Left lung solidified. Gen- 

 eral condition extremely cachectic, so emaciated and frail that 

 his tenure of life seemed very uncertain. His blood showed 

 3,260,000 red corpuscles of exceedingly poor quality, variant 

 in size, malformed in shape. The white corpuscles numbered 

 14,500, of which 87 per cent, were polynuclears, 7.3 per cent, 

 small lymphocytes (including plasma cells), and 5.6 per cent, 

 large mononuclears. The polynuclears are recorded as of red- 



