140 THE PROTEOMORPHIC THEORY AND THE NEW MEDICINE 



purple nuclei, not sharply defined from the cytoplasm, which was 

 opalescent, and distinctly reddish. The large monocytes were 

 typical, dark, with opaque cytoplasm. 



This patient was not treated in my office, but by an associated 

 physician, and a second blood count was not made for six weeks, 

 at which time the red corpuscles had risen to 4,395,000 in number 

 and the white corpuscles had come down to 12,500, of which 

 78.3 per cent, were polynuclears, 7.3 per cent, small lymphocytes 

 (no plasma cells), and 14.3 per cent, large monocytes. The red 

 cells in addition to their spectacular increase in number were 

 much more normal in appearance. A good many platelets had 

 appeared, and free microblasts, often large, of which there had 

 been none at the earlier period. The polynuclears were very 

 acidophile and granular, with full cytoplasm. There was ex- 

 treme progression to the left in the Arneth sense that is to say 

 a very large number of single-nucleated neutrophiles. The large 

 monocytes were large and fairly typical ; the cytoplasm dark, but 

 clearly differentiated from the nucleus. The number of these 

 large monocytes had increased, as will be observed, by 250 per 

 cent. The change in size and quality was not less conspicuous. 



A fairly plausible interpretation of these microscopical find- 

 ings, and one consonant with the clinical history and the known 

 pathology of such cases, would be that there was marked bac- 

 terial infection (indicated by the leucocytosis, with conspicuous 

 preponderance of polynuclears), but that there was also marked 

 general protein infection, comparable to the infection from can- 

 cer, the solidified lung mass having many of the characteristics 

 of a malignant neoplasm. The response to proteal treatment, 

 indicated by increase of red corpuscles, decrease of white, de- 

 crease of the polynuclear preponderance, and marked increase of 

 large monocytes may be taken as suggesting interesting possi- 

 bilities of proteal treatment for tubercular cases even at a late 

 stage of unfavorable development. 



In another late-stage case of pulmonary tuberculosis the red 

 corpuscles before the administration of Proteals numbered only 

 3,964,000, and were of such quality (90 per cent, diminutive and 

 misshapen) that their functional efficiency must have been far 

 more than proportionately reduced. After seventeen days of 

 Proteal treatment (doses of 3 to 7 minims of Nos. 37 and 45), 

 the red cells were metamorphosed in character, and increased in 

 number to 4,500,000. Clinically there was striking improvement. 

 Temperature and pulse reduced to normal (from 101 and 115, 

 respectively) ; cough much less ; better appetite and sleep ; 

 strength and sense of well being so greatly improved that the 

 patient asked to be allowed to go back to work. Prior to be- 

 ginning treatment her physician had told her that she had but 



