144 THE PROTEOMORPHIC THEORY AND THE NEW MEDICINE 



A pioneer in any line of research work must always await with 

 interest corroboration of his results by other workers. Naturally 

 I shall be pleased to have reports at all times from candid ob- 

 servers, whether by way of corroboration or criticism ; but I 

 repeat that the evidence already in hand, based on my personal 

 observation, is so comprehensive, so unequivocal, and so con- 

 vincing that I await the ultimate verdict of the profession with 

 absolute confidence. 



All this, however, is in effect a digression. Let us again take 

 up briefly the interpretation of the blood changes that are brought 

 about by Proteal medication, in so far as they are of practical 

 interest and importance to the practitioner ; following with some 

 explicit hints as to the practical administration of the new method 

 in cases of malnutrition of sundry types, from simple anaemias 

 to the profound cachexia of tuberculosis and carcinoma. 



AN INTERPRETATION OF CORPUSCULAR ACTION 



As regards a somewhat more detailed interpretation of the 

 blood count, and in particular the differential count, there are 

 certain opinions that I hold provisionally, regarding which more 

 elaborate publication will be made elsewhere, to which brief 

 attention may be given. As elsewhere pointed out, this subject 

 is one in which very little work has been done, and regarding 

 which the opinions of the pathologists are altogether vague. So 

 far as I know, the question has not hitherto been asked, let alone 

 answered, as to why in normal blood the polynuclears number 

 60 to 70 per cent, of the total leucocytes, the lymphocytes 20 to 

 25 per cent., and the large monocytes and eosinophiles and baso- 

 philes make up a relatively insignificant population. Yet there 

 must be reasons why there is this distribution of corpuscles in 

 normal blood; reasons associated with the variant functions of 

 the different types of cells. 



In attempting to interpret the observed blood changes under 

 Proteal treatment, peculiar difficulties are encountered in the 

 fact that the physiological activities of the corpuscles have been 

 but vaguely understood. 



Ordinarily, the pathologist is guided in the interpretation of 

 what he sees by known physiological laws. The student of 

 microscopic pathology has for guide the well-recognized findings 

 of the histologist. But in the present instance such aid is not 

 available. We have, to be sure, records as to the relative num- 

 bers of different types of. blood corpuscles in health and acute 

 infections. The further fact is available that the polynuclears 

 appear to be especially concerned in the direct battle against in- 

 vading bacteria. But with that antecedent knowledge practi- 



