THE SCIENCE AND ART OF PROTEAL THERAPY 157 



polynuclears, 63.4 per cent. ; large monocytes, 16.9 per cent. ; small 

 monocytes, 16.8 per cent. 



In each of these groups of cases, it will be observed, the 

 striking anomaly is the preponderance of large monocytes. That 

 fact, however, is one that scarcely needs emphasizing for the 

 reader of the present work. That such an increase does occur, 

 as the direct result of protein treatment, and that this increase 

 is associated in a beneficial way with the handling of foreign 

 protein products in the system, are inferences that constitute 

 the substructure of this book and the guiding principles of the 

 investigations on which it is based. They are deductions from a 

 wide range of original studies, and they are conceived to con- 

 stitute a significant contribution to physiology, pathology, and 

 therapeutics. That they constitute valid observations and deduc- 

 tions, I entertain not the remotest doubt. Nevertheless, I would 

 repeat, in leaving this aspect of the subject, that there is no 

 necessary association between the validity of these observations 

 and deductions and the value of protein medication as a thera- 

 peutic agency. 



In my original studies, clinical observation and microscopical 

 observation have gone hand in hand. Each has found support 

 in the other. But I repeat that my pioneer work with the micro- 

 scope has not as yet been checked by the observation of any 

 considerable number of cases in the hands of other workers; 

 whereas the clinical results have been duplicated by some hun- 

 dreds of physicians administering Proteals from my laboratory 

 in accordance with my methods. Under such circumstances, it 

 must freely be admitted that the clinical findings might stand 

 though the microscopical findings and the theoretical explana- 

 tions failed of corroboration. As I have stated, no one should 

 condemn the method merely because he does not agree with the 

 theoretical interpretation here presented. 



Having made that concession, however, let me not leave the 

 subject without reiterating my expectation that clinical observa- 

 tion and microscopical observation will both find abundant war- 

 rant in the findings of any competent observer who makes scien- 

 tific investigation of the new method ; coupled with the statement 

 that the interpretation of the observed facts in the light of the 

 Proteomorphic theory constitutes a working hypothesis that must 

 hold the field until challenged by some new discovery of which 

 we have no present inkling. In a word, repeating the phrase 

 with which this book is introduced, and modifying it to fit the 

 present purpose, it must be admitted that the observations and 

 theories of protein metabolism and Proteal therapy presented in 

 the foregoing pages are important if valid, and I have the utmost 

 confidence that they are valid. 



