164 THE PROTEOMORPHIC THEORY AND THE NEW MEDICINE 



peutic advantages in using a combination of proteins rather than 

 a single protein. I believe that experience does not as yet 

 justify a positive answer. I have studied the matter very care- 

 fully through observation both of clinical symptoms and the 

 blood response, and I am not prepared to say positively that I 

 have seen decisive evidence of a difference, qualitative or quan- 

 titative, between, for example, the use of Proteal No. 39, which 

 contains only the protein of alfalfa seed, and Proteal No. 45, 

 which contains also the proteins of alfalfa meal and millet seed. 

 It is difficult to avoid the feeling that there must be a differ- 

 ence, but this may be based merely on a preconception. I have 

 thought it worth while to test the validity of the preconception 

 by making the elaborate combinations above listed, and numer- 

 ous others. I think the matter will not be definitely settled until 

 many thousands of cases have been treated with single proteins 

 and with proteins in combination. There would seem to be 

 theoretical warrant for the assumption that, inasmuch as each 

 protein has its own individual response, a combination of pro- 

 teins would produce a more varied and, in the aggregate, a more 

 pronounced response than a single protein. But whether or not 

 this should prove to be the fact, there is nevertheless abundant 

 reason for making the combinations, inasmuch as they give oppor- 

 tunity for the introduction of a new type of protein from time 

 to time, in accordance with the established therapeutic principle 

 that it is desirable to change the type of protein, or introduce 

 a new type, when a certain degree of immunization or cytogenic 

 apathy has been produced. 



A convenient practical method, for example, is to begin treat- 

 ment of a case, let us say, of tuberculosis, with Proteal No. 39, 

 alfalfa seed protein; shifting presently to a combination of 

 alfalfa seed and alfalfa meal (Proteal No. 60), and then in due 

 course to No. 45, which introduces millet seed protein as an 

 additional element. A little later the shift may be made to 

 Proteal No. 65, which, still retaining the alfalfa and millet pro- 

 teins, introduces also the proteins of rape seed and mustard 

 seed. Still later an entire shift may be made to No. 75, with its 

 five new proteins, or to No. 100, which retains the original pro- 

 teins in relatively reduced quantities and introduces five new ones. 



An alternative procedure, which has been observed to work 

 well in many cases, is to begin with a combination, say No. 45 

 or No. 65, and after a time to shift to a single one of the con- 

 stituents. For example, begin with the combination containing 

 alfalfa seed, alfalfa meal, millet seed, rape seed, and mustard 

 seed (No. 65), and presently shift to No. 39, alfalfa seed protein 

 alone, beginning with a relatively small dose and increasing grad- 

 ually, until, obviously, at maximum dosage the maximum re- 



