176 THE PROTEOMORPHIC THEORY AND THE NEW MEDICINE 



improvement had resulted from these measures. Then the strik- 

 ing changes observed in the first patient, as above noted, led to 

 the decision to administer the Proteal treatment in this second 

 arthritis case, although the treatment had theretofore been ap- 

 plied solely to patients suffering from cancer. The administration 

 of the Proteal extract was begun on the 28th of May, 1915. 



The injections were continued over a period of nine months. 

 At the outset the patient had been taking 40 to 60 grains of 

 aspirin each twenty-four hours to relieve the pain. The amount 

 was promptly diminished in the course of the first three weeks 

 of the Proteal treatment, and in the course of two months the 

 drug was entirely discontinued. 



Here is the report on the treatment and its results: 



"During the earlier months of the treatment the injections 

 were given every second day, during the last four months the 

 interval between the injections was gradually increased until 

 finally an injection was given only once a week. The patient's 

 improvement was gradual but definite, and she finally reached 

 and maintained a state of health satisfactory in every respect. 

 The bony changes about the affected joints have never been re- 

 lieved and it seems very doubtful if they ever will be. How- 

 ever, the infiltration and thickening of the soft tissues has been 

 entirely relieved. During the past six months this patient has 

 had no treatment whatever. She has been in excellent health, 

 has gained twenty- four pounds in weight during the course of 

 the treatment, and during the past summer has been unusually 

 active, playing tennis, swimming and doing a variety of house- 

 hold work, using her hands with perfect freedom and comfort 

 for such mechanical operations as writing, fine sewing, etc." 



The clinical progress of this case was matched by the modi- 

 fications in the blood conditions. Starting with a red blood 

 count of a little over two million and hemaglobin of 70 per cent., 

 the records show that on the 17th of September the red blood 

 count was 3,900,000, the hemaglobin 79 per cent. On the 14th 

 of December the red count was 4,444,000, the white count 6,700, 

 the hemaglobin 90 to 95 per cent. On the 27th of December the 

 red corpuscles numbered 5,280,000, the white corpuscles 8,000. 

 The differential count, at a time when the treatment was most 

 actively pursued, showed 53 per cent, polynuclears, 25.5 per 

 cent, large monocytes, 12 per cent, small lymphocytes, and 9.5 

 per cent, eosinophiles. At a later date (December 27th), when 

 the patient was receiving only weekly Proteal treatment, the dif- 

 ferential count showed polynuclears, 14.5 per cent, large mono- 

 cytes, 22.5 per cent, small lymphocytes, and 3 per cent, eosino- 

 philes. 



It is significant that two years have now elapsed since treat- 



