THE SCIENCE AND ART OF PROTEAL THERAPY 207 



of a million leucocytes to the cubic millimeter, with red count 

 not far above three million ; the smear showing the leucocytes to 

 be small compact lymphocytes almost exclusively. 



The clinical symptoms that led the patient to come for treat- 

 ment consisted chiefly of extreme enlargement of glands at each 

 side of the neck, in the region of the parotids ; enlargement of 

 lymphatic glands at the back of the neck and head, in the axil- 

 lary regions and inguinal regions and elsewhere ; associated with 

 severe pains, particularly located in the region of the enlarged 

 glands at the back of the neck and head. 



The patient was placed under Proteal treatment, the mixture 

 of the proteins of alfalfa seed, alfalfa meal, and millet seed (Pro- 

 teal No. 45) being administered in doses of from three to eight 

 minims on alternate days ; a shift being subsequently made to 

 rape seed protein (Proteal No. 42). There was a very prompt 

 response, in that general reduction in the size of the enlarged 

 glands took place. The glands at the sides of the neck were 

 reduced so markedly as to alter the patient's appearance very 

 noticeably. The lymphatic swellings at the back of the neck 

 and head, and in axillary and inguinal regions were greatly re- 

 duced in size or altogether disappeared. The pain, which had 

 been persistent, disappeared and has not recurred. Nor has 

 there been any tendency to return of the glandular enlargements, 

 except that a temporary swelling appeared in each mastoid region 

 following an attack of influenza (shortly after convalescing), 

 which swelling the patient ascribed to "catching cold" through 

 sitting in a draft. 



I shall not go further into the clinical details of this patient's 

 history in the present connection. We are here concerned with 

 the blood conditions, which are of the most striking and (in con- 

 nection with the clinical state), even mystifying character. After 

 two weeks of Proteal treatment, there was a very marked modifi- 

 cation in the character of the leucocytes, in that large number 

 of cells appeared which were two or three times the size of the 

 prevalent lymphocytes, and which took the stain much more 

 faintly, and appeared somewhat vague and ragged in outline in 

 contrast with the sharply rounded, bullet-like lymphocytes that 

 clustered everywhere so thickly as to remind one of grapes on 

 the vine. These large cells could not well be classified other than 

 as large monocytes, although only by rare exception could one 

 be found that showed a distinct nucleus and dark-stained cyto- 

 plasm. In general these large cells, like the small lymphocytes, 

 showed no cytoplasm whatever. They appeared to be all nucleus, 

 with vague boundaries. They gave one the impression of lying 

 in the background as it were, and at a different level, from the 

 protruding grape-like small lymphocytes. The red corpuscles, 



