234 THE PROTEAL TREATMENT OF CANCER 



Residues, Extracts, and Emulsions, include Coca-Gilman Ex- 

 tract, or Emulsion; Vaughan Residue; the Fichera Emulsion, 

 and Autolyzed Cancer or Normal Tissue. 



Of serous exudates and body fluids there is a long list, includ- 

 ing Hodenpyl's Ascitic Fluid from a cancer subject; Normal 

 human Blood Serum; blood serum of the horse and donkey; 

 Hydrocele Fluid; Spermatocele Fluid; Ascitic Fluid from the 

 subject of alcoholic cirrhosis; Ascitic Fluid from the subject of 

 cardiac insufficiency ; and Pleuritic transudate resulting from 

 broken compensation. 



Of Opotherapeutic Measures (organotherapy) the examples 

 include (1) "Antituman" of Oestriech made from embryological 

 cartilage and arteries from which a supposedly immunizing sub- 

 stance chondroitin-sulphate is extracted; (2) Thymus Gland 

 Extract; (3) Extract of Sheeps' Thyroids; and (4) Pancreatic 

 enzymes, Trypsin and Amylopsin as widely exploited a few years 

 ago under the auspices of Beard. 



As to the status of these various treatments, perhaps I cannot 

 do better than to quote Bainbridge's summary to the effect that : 

 "Many of the agents have been discarded, with practically a con- 

 sensus of opinion against their efficacy ; others continue to receive 

 a certain amount of attention, largely because no definite test of 

 their value has been made upon a convincing basis; while still 

 others are being given careful consideration by a sufficient num- 

 ber of skilled clinicians to warrant the hope that a decision, pro 

 or con, will be soon forthcoming." 



I would add, however, that there is a considerable body of 

 evidence to show that a good many of these diverse agents have 

 seemed to produce beneficial effects in a certain number of cases, 

 and that several of them are still actively employed and enthusi- 

 astically championed by a number of physicians. Note, for 

 example, the report of Klinger in the Correspondenz-Blatt fur 

 Schiveizer Aerzte for Sept. 23, 1916, on the results obtained 

 with autolysates, to which fuller reference will be made in another 

 connection. That no one of them fully meets the hopes and 

 expectations of its originators may, doubtless, be accepted as 

 fairly demonstrated. But I think it must also be clear that even 

 tentative results would hardly have been attained with so great 

 a variety of animal extracts unless some general principle was 

 involved that gave the different treatments affinity. 



It is my belief that the principle in question is the presence of 

 animal or bacterial proteins in all of the various compounds in 

 question. In the case of Beard's Pancreatic Enzymes there are 

 also present digestive ferments closely comparable to those known 

 to be evolved by the white blood corpuscles, the manner of action 

 of which will be dealt with presently. 



