266 THE PROTEAL TREATMENT Of CANCER 



The average results of fourteen unselected cases under the 

 protein treatment are summarized thus: At the beginning of 

 treatment haemoglobin index 89 per cent., red corpuscles 4,500,- 

 000, white blood corpuscles 8,878 ; with 68 per cent, polymorphs ; 

 14.9 'per cent, large monocytes ; 14 per cent, small lymphocytes ; 

 .65 per cent, eosinophiles ; and 0.32 basophiles. At a later stage 

 after an average of 42 days of protein treatment, haemoglobin 

 index 96 per cent.; red corpuscles 4,930,000, and white blood 

 corpuscles 8,107; with 62 per cent, polymorphs; 18 per cent, 

 large monocytes ; and 16 per cent, small lymphocytes ; 3 per cent, 

 eosinophiles ; and 0.35 basophiles. 



SOME PRACTICAL HINTS 



It is almost axiomatic to say that observation of the blood 

 count must in future be regarded as indispensable as a guide to 

 dosage and frequency of administration in carrying out the pro- 

 teal treatment of cancer. This is particularly true, however, after 

 treatment has been continued for a period of five or six weeks. 



Up to that time, there is almost certain to be favorable progress 

 of the case if the remedy is pressed pretty actively from the outset, 

 the doses being carried to the point of securing a pronounced gen- 

 eral reaction on at least one occasion, and subsequently modified 

 so that there is a mild reaction. 



During this stage, there will usually be observed a pronounced 

 increase of red blood corpuscles; but this is no more notable than 

 the lymphocytosis, with marked preponderance of the large cells. 



It should be observed, however, that the activities of the mono- 

 cytes in beginning the decompounding of cancer cells may be so 

 great as to put so severe a tax on the energies of the red blood cor- 

 puscles that their numbers will be for a time materially reduced, 

 even when the case is progressing favorably. 



A very good illustration of this is furnished by case 309, in 

 which there was a large abdominal sarcoma located near the spine, 

 which had been declared irremovable after an exploratory incision. 

 On the 19th of September, 1915, two days after beginning the 

 Autolysin treatment, this patient showed a red blood count of 

 5,066,000 ; with 75 per cent, polymorphs, 17 per cent, large mono- 

 cytes ; 6 per cent, small lymphocytes and 2 per cent, eosinophiles. 

 Two weeks later the red blood count had decreased 3,412,000; but 

 in the meantime the polynuclears had decreased to 59 per cent. ; 

 there being now 22.5 per cent, large monocytes, 16 per cent, small 

 lymphocytes, and 2.5 per cent, eosinophiles. 



Taken by itself, the decrease in red blood corpuscles might seem 

 alarming; but that the above interpretation of this decrease is 

 correct is suggested by the fact that the patient went ahead stead- 



