280 THE PROTEAL TREATMENT OF CANCER 



It is unfortunate that details are not given as to the remaining 

 types of leucocytes, but it is obvious that a simple computation 

 shows that at the earlier stage of this experiment, when the tumor 

 was seemingly overmastering the system, the large mononuclears 

 and the eosinophiles together aggregated only 19 per cent, of the 

 leucocyte count; whereas at a later stage, when the tumor was 

 spontaneously regressing, the large monocytes and the eosino- 

 philes together must have aggregated 36 per cent, of the total 

 count, a number far in excess of the normal, which, according 

 to Price Jones, is represented by 21.5 per cent, of large mononu- 

 clears and 0.14 of eosinophiles. 



These observations of general lymphocytosis in cases of mouse 

 tumors that are progressing to recovery have obvious interest as 

 supplementing the observations of Da Fano to the effect that 

 lymphocytes appeared in great numbers about inoculations of 

 immunizing material during the evolution of resistance, and that 

 in growing carcinomata the presence of the lymphocytes in great 

 numbers was clearly associated with a local healing. 



Further association between the corpuscles and the processes 

 of immunization was suggested by the observations of Lambert 

 and Haynes that rat sarcoma would grow in the plasma of immu- 

 nized mice quite as vigorously as in that from normal or tumor- 

 bearing animals, an observation that obviously links with the 

 observations on the curative properties of entire blood versus 

 serum, as recorded at the beginning of this chapter. 



From the present standpoint these observations as a whole have 

 quite exceptional interest because they reveal modifications of the 

 leucocyte count in mice in which tumors are undergoing regres- 

 sion that are singularly comparable to the records of the favorable 

 case of human cancer under protein treatment observed by me 

 and recorded in great detail before I had so much as heard of Dr. 

 Baeslack's experiments. It will be recalled that charts were pre- 

 sented to illustrate graphically the fact that in cases that pro- 

 gressed most favorably under -Proteal treatment the polynuclears 

 and the small lymphocytes tended to approach the normal in 

 numbers, whereas the large monocytes increased very markedly 

 and held at high level. 



It would appear that the same formula could be applied to Dr. 

 Baeslack's convalescing mice; although -the observer himself ob- 

 viously failed to appreciate the significance of the large monocyte 

 count, his attention being fixed solely on the polynuclears and 

 small lymphocytes. Possibly he had overlooked, or was not aw-are 

 of, the normal balance of leucocytes in mice (which, as just noted, 

 is very different from that of the human subject), and hence did 

 not realize that the fall of polynuclears to about 16 per cent, and 

 the rise of lymphocytes to about 50 per cent., represented only 



