ANIMAL EXPERIMENTATION AND PROTEAL THERAPY 295 



24.4 per cent. ; eosinophiles 5.6 per cent. ; basophiles 1.2 per cent. 

 At this time study of the red cells showed a great abundance 

 of normoblasts and free microblasts. Two weeks later, however, 

 these had altogether disappeared (October 18th). The large 

 monocytes, of normal type, now numbered 9.6 per cent. ; the poly- 

 morphs stood practically unchanged at 59.6 per cent. ; the lym- 

 phocytes had fallen to 19.6 per cent., and there were only 1 per 

 cent, each of eosinophiles and basophiles. A month later (No- 

 vember 16th), the count showed continued progress, the poly- 

 nuclears having fallen to 55.3 per cent., whereas large mononu- 

 clears had risen to 13.3 per cent., small lymphocytes to 27.3 per 

 cent., and eosinophiles to 4 per cent. 



The significant feature of this blood modification was the 

 transformation from abnormal types to normal types of large 

 mononuclears and the very notable increase of lymphocytes. The 

 patient's general condition had meantime improved and there was 

 a tendency to softening of the tumor mass in the breast, flattening 

 of a large lymph node in the axilla, and marked regression of a 

 subclavicular mass. It was not to be expected, however that very 

 marked regression of the tumor would occur until the large mono- 

 cyte count had been brought to a much higher state. The ulti- 

 mate result must be left for future record. I mention the case 

 here merely to illustrate a rather exceptional modification of the 

 blood count, and to emphasize the point that in a case of such 

 chronicity, in which the lymphatic system is seriously involved, 

 with metastases, one must be content to go slowly, expecting no 

 such spectacular metamorphosis as was recorded in the letter 

 above quoted. 



By way of contrast, note the progress of another recent case 

 (No. 497) in which there was primary involvement of both 

 breasts not far advanced. A surgeon had advised removal of both 

 breasts, yet malignancy was considered doubtful by me until the 

 blood count showed the following : polynuclears, 48.9 per cent. ; 

 large mononuclears (including myelocytes), 16.6 per cent.; small 

 lymphocytes, 30.5 per cent.; eosinophiles, 4 per cent. The re- 

 sponse to the proteal treatment was immediate; the patient re- 

 ported a transformation in general health, and the blood count 

 after three weeks of treatment (November 16, 1916) was: poly- 

 nuclears, 43.6 per cent. ; large monocytes, 21 per cent. ; small lym- 

 phocytes, 33.6 per cent.; eosinophiles, 1.6 per cent. 



The rapid response of this patient as contrasted with the pre- 

 ceding one may be ascribed, in all probability, to the early stage 

 of development of the neoplastic growths. 



With the emphasizing of this point, I may perhaps advantage- 

 ously leave this aspect of the subject, reiterating the opinion that: 

 here, as in so many other fields of pathology, there is a tremen- 



