302 THE PROTEAL TREATMENT OF CANCER 



the knife of the surgeon. It is true that the Proteals have hitherto 

 been applied almost exclusively in inoperable cases. But in more 

 than one instance it has happened that, under the influence of the 

 remedy, a cancerous mass too widely extended for removal has 

 regressed until the remaining mass is readily operable. In such a 

 case, I would strongly urge that the co-operation of the surgeon 

 should be sought, and the mass excised. By so doing, we relieve 

 the system of the patient of the burden of absorption of a mass 

 of protein tissue. 



It will not usually be necessary, however, to make the surgical 

 operation so radical, when Proteals are used, as it otherwise must 

 be ; inasmuch as the metastatic glands and the neighboring tissues 

 which at best the surgeon can remove but inadequately are 

 peculiarly subject to the proteolytic enzymes evoked by the ad- 

 ministration of the hypodermic remedy. 



It goes without saying, now that Proteal therapy supplies a 

 means hitherto not available, to stimulate the production of the 

 blood corpuscles and whip up their enzyme-forming capacities, 

 that no surgeon of judgment will think of performing an opera- 

 tion for cancer without supplementing his surgical procedure with 

 the use of Proteal remedies before and for some time after the 

 operation. 



It is essential, of course, to bear in mind the familiar phenom- 

 ena of anaphylaxis, and to continue the administration of any 

 given protein daily, or at intervals of two or three days at the 

 most, until immunization is attained. It would obviously be in- 

 advisable, after administering a given protein, to wait ten days 

 or two weeks before administering a second dose of the same 

 protein ; since it is precisely under such conditions that the phe- 

 nomena of anaphylaxis in its alarming form are likely to be 

 developed. One protein, as is well known, does not fully im- 

 munize the system against another. Indeed, it is precisely this 

 fact, as already pointed out, that furnished the basis for the 

 theoretical administration of a series of proteins along the lines 

 just suggested. 



It has been pointed out that there is a wide range of variation 

 among patients as regards their response to a given quantity of 

 any foreign protein. The degree of susceptibility of individual 

 patients must be determined by experiment. 



It should be recalled, however, that in giving maximum doses 

 one is introducing a relatively large quantity of foreign proteins 

 and that these proteins must be dealt with by the bodily enzymes. 

 So it may be accepted as a general principle of medication that 

 the smallest dose that will produce a vigorous enzymic (corpus- 

 cular) response is the best dose. 



There may come a time in the course of any individual case, 



