58 SPIROCILETES. 



With material containing it they inoculated a monkey 

 (Macacus rhesus) and thus produced a local lesion at the 

 point of inoculation, followed by the appearance of 

 other nodules at a distance. They further inoculated 

 a second monkey from the first, also with positive re- 

 sults. The spirochaetes were found in all the lesions. 

 These spirochaetes so closely resembled Sp. pallida 

 that they were at first mistaken (?) for this organism. 

 It seems possible that in this case either a syphilitic 

 adenitis was mistaken for lymphadenoma, or that a 

 secondary infection with Sp. pallida occurred in a 

 patient suffering from this disease. 



ULCERATIVE GRANULOMA. 



Spirochaetes were first found in the disease called 

 ulcerative granuloma of the pudenda by Wise, who 

 stated that some forms resembled Sp. pallida and 

 others Sp. pertenuis. They have since been found in 

 this disease by MacLennan and by Cleland. They 

 exist in the deep layers at the base of the ulcer, at some 

 distance from the surface, and may be found in the 

 blood-vessels. Bacteria are present along with the 

 spirochaetes. The pathogenicity of these organisms 

 cannot be held to be proved as yet, but their position 

 deep in the tissues is against a purely saprophytic 

 character. * 



VINCENT'S ANGINA. 



Spirochaetes are found along with fusiform bacilli in 

 the disease called Vincent's angina, and also in some 

 other conditions in which there is necrosis of tissue (e.g., 



1 M. Carter states that he has found in a case of this disease, pro- 

 tozoon parasites in the form of minute rounded bodies within the 

 cells. He believes that they are related to Leishmania donovani 

 (Lancet, 1910, II, 1128). 



