PATHOGENESIS 307 



There is a local as well as a general anaphylaxis. . . It certainly 

 is not one of the minor difficulties of the question to find, not only the 

 blood and viscera, but all the tissues, skin, and lymphatic glands satu- 

 rated with the poison. 



Prof. Eichet tells us: 



Since in all these cases of anaphylaxis in man the injection has 

 never been given intravenously, and nevertheless the symptoms have 

 been very serious, and since a large number of experiments on animals 

 have proved that intravenous injections induce more rapid and more 

 intense symptoms than subcutaneous injections, it can be concluded 

 definitely : 



1. That man is extremely sensitive to the anaphylactic reaction. 



2. That intravenous second injections invariably constitute Jin 

 actual danger. 



Verb. sap. sat. 



As regards the anaphylactising substances, Prof. B-ichet 

 tells us that : 



Up to the present everything seems to prove that colloids alone are 

 able to induce it ; just as colloids alone are capable of producing the 

 reactions of immunity. . . . Innumerable investigators have shown 

 that it follows the injection of heterogeneous sera such as ox serum, eel 

 serum, goat serum, without exception. 



Iii previous chapters we have already seen that for 

 biological (bio-economic) reasons the use of colloids must be 

 qualified, that it is only certain groups of colloids that 

 play a prominent part in the evolution of taste and of smell, 

 and that other albuminous substances easily give rise to over- 

 stimulation with resulting fatigue and to inductive decom- 

 position. It is perhaps in no small measure due to their 

 inability to react upon such important guardians of integrity 

 as the organs of smell and of taste that insipid colloids are so 

 apt to be indulged in to excess, and thus further to pervert the 

 sense of proportion. Being insipid they require to be mixed 

 with sapid substances, and it is as a means of obtaining at least 

 a modicum of such sapid substances, and of vitamines which 

 are only secondarily associated with such colloids as flesh- 

 foods, that an ill-feeder, as we have seen, is frequently obliged 

 to go to excess. But there is no compulsion upon organisms to 

 resort to these questionable colloids for food supplies, for 



