PATHOGENESIS 323 



dose, the animal recovers from the anaphylactic shock, but it dies ten, 

 twenty- four, or forty-eight hours afterwards. Such chronic anaphylaxis 

 is not absolutely peculiar to the dog ; for rabbits, at the end of several 

 successive injections of toxins or even of serum, at length die of cachexia. 



Comment almost seems superfluous. The animal recovers 

 from the anaphylactic shock but dies of the poison. There 

 is an end of it. To some the recovery may appear as too dearly 

 purchased. Elimination of poisoned material is frequently 

 associated with death, and we are thus strikingly reminded of 

 those frequent instances of nemesis of reproduction, as in 

 parasitism, where the mother's life is frequently the price of 

 parturition, i.e., elimination. Reproduction is in such cases a 

 sort of elimination of what has become an unendurable burden 

 on the parent, and we know that in extreme cases the general 

 morbidity of the species is such that the young actually drain 

 the parent to death. The embryo in the latter cases shows 

 pathological transmission, and, such is the nemesis of bio- 

 logical evil upon a species, that the bringing forth of this 

 offspring, like the elimination of a rank anaphylactising 

 poison, proves costly and precarious and frequently fatal. 



Having called for the tune "em garstig Lied," as 

 Goethe would say a parasitic species must thus in the end pay 

 the piper. 



In order to explain this slow death of anaphylactised animals, it 

 must not be supposed that the anaphylactic poison, apotoxin, persists 

 throughout the tissues ; for most frequently, in dogs at least, the period 

 of recovery has commenced, showing clearly that in those animals which 

 ought to die slowly, as well as in those which ought to recover, apotoxin 

 has disappeared. The phenomena succeed each other in this order. 

 Firstly, there is the anaphylactic shock, which is violent and leaves the 

 animal for half an hour or an hour in a state of impending death, But, 

 except in very rare instances, death does not follow immediately, and 

 evidences of recovery are apparent. The dog gets up, walks about, 

 seems almost cured, although diarrhoea and tenesmus continue. In 

 spite of this apparent recovery, it becomes very weak some hours later; 

 it cannot rise from the ground ; it has profuse intestinal haemorrhages, 

 complete inertia, insensibility, and an abnormally low temperature. 



In all probability it dies of lesions, visible or invisible, produced 

 by the apotoxic poison. Sublata causa non tollitur effectus. The injuries 



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