PATHOGENESIS 325 



injection of white of egg into the stomach or small intestine of a rabbit, 

 or of actino-congestine into the stomach or small intestine of the dog, 

 does not result in anaphylaxis ; while, on the contrary, anaphylaxis 

 does result when the first injection is made into the large intestine. 



Clearly this indicates that the true reliance of an animal 

 must be on the integrity of its alimentary functions and of its 

 intestinal tract and its power of self -protection by their means. 



" Normal digestion entails neither intoxication nor 

 anaphylaxis." Precisely. It entails instead sobriety and 

 industry, i.e., biological integrity. 



As digestion varies, both in its duration and in the formation of 

 various products, in different species and different individuals, so the 

 ingestion of similar albuminoids may lead to very different results 

 according to the species and the individuals taking them. 



This is only what might be expected. The following 

 experiment by Prof. Richet shows that the intensity of the 

 morbid symptoms increases with the intensity of the in-feeding. 

 Of nine dogs 



three were fed on raw horse-flesh, three on milk, and three on eggs. 

 At the end of forty days I tried to find out if they were anaphylactised 

 to horse-flesh, milk, and eggs respectively. The special feeding was 

 suspended during the last thirty days in the case of one dog in each 

 series in order to eliminate the possibility of anti-anaphylaxis. The 

 three dogs fed on milk and injected with milk as an exciting injection 

 presented no symptom. One of the three dogs fed on egg albumen 

 firstly and later injected with it had transient and mild symptoms of 

 pruritus. Of the three dogs fed on horse-flesh and later injected with 

 muscle serum from horse-flesh, one presented very distinct symptoms of 

 anaphylaxis great fatigue, with prostration and inability to walk. 



This shows that egg albumen (in excess) is worse than milk 

 (in excess), and horse-flesh worse than either, and this is what 

 in my view might be expected, since in milk (a " love-food ") 

 no life is sacrificed; in eggs (also "love-food") incipient life 

 is sacrificed, and in the flesh diet the predaceous quality of the 

 food is obvious. 



Prof. Richet asks : " Is it not the inevitable conclusion to 

 be drawn from these experiments that anaphylaxis sometimes 

 does develop as a result of alimentary ingestion? " 



