248 VACCINE TREATMENT IN THE PREVENTION OF DYSENTERY 



the Flexner organism had been recovered this same organism 

 was also recovered from the flies. It is interesting to note that 

 the B. dysenteriae are carried by the ordinary house fly and 

 may be one of the causes for spreading this infection during the 

 months when flies are so abundant. 



This investigation is very limited and the number of cases 

 treated are entirely too few to draw any conclusions from, yet 

 the following conclusions may not be amiss: First, the vaccine 

 in no case did harm and the reactions in the majority were very 

 mild and of short duration. Second, cases which bacteriological- 

 ly were proved to have the B. dysenteriae present, but in a clinic- 

 ally unrecognizable form, were not affected in any way different 

 from the cases which were culturally negative. This may in 

 part be due to the fact that this mode of vaccination produces 

 an immediate passive immunity, while the bacterial vaccine is 

 producing an active immunity. In conclusion, the work was of 

 enough interest and holds out a possible means of preventing 

 the great mortality from infantile dysentery during the summer 

 months. 



We wish to express our indebtedness to Dr. John Lovett 

 Morse through whose effort the fund for carrying on this work 

 was raised, and to Professor Milton J. Rosenau for his super- 

 vision and suggestions. We wish also to thank Dr. Grace Atkins 

 Gordan for her valuable assistance in getting specimens and 

 for her clinical observations in many of these cases, and to the 

 undergraduate students who assisted in many ways. 



BIBLIOGRAPHY 



iShiga, Centralblatt fur Bakteriologie, 1898, Bd. XXIV. 



2 Shiga, Deutsche med. Wochenshrift, 1903, p. 327. 



3 Ludke, Centralblatt fur Bakt., 1905, p. 512 et 649, Bd. XXXIX. 



4 Dopter, Vaccination preventive centre la Dysenterie bacillaire, Annales de 

 1'Institut Pasteur, Sept. 1909, pate 677. 



5 Vaillard et Dopter, Annales at 1'Institut Pasteur, 1903. 

 6 Rosculet, Wiener klin, Wochenshrift, no. 35, August 30, 1906. 

 'Michiels, Poitou Medical, February, 1909. 



8 Shiga, in Report of the Japanese naval medical and sanitary features of the 

 Russo-Japanese war. (W. Braisted, p. 50, Washington. 1906. 



"Journal of Medical Research 23, 3 : 481. 



10 Besredka, Annales de 1'Institut Pasteur, 1903. 



n W. P. Lucas, J. G. Fitzgerald, E. H. Schorer, in Methods of Serum Diagnosis 

 in Bacillary Dysentery (Infections Diarrhoea) in Infants. The Journal of 

 the American Medical Association, February 5, 3910, Vol. LIV, pp. 441-446. 



