140 



FEBRIFUGES 



quent dilatation of the surface vessels, loss of heat is greater 

 when animals are asleep than when awake. Conversely, 

 more heat is produced when the animal is in active motion, 

 and blood circulates freely through the heat-producing 

 apparatus of the muscles and glands. Small animals, 

 having a cooling surface relatively larger than their internal 

 heating appliances, are more rapidly cooled than large 

 animals. A centre in the corpus striatum appears to regu- 

 late the production of heat (thermo taxis), and certain 

 agents (antipyretics) appear to develop their effects by 

 acting on this centre. 



Febrifuges may be divided into two classes those which 

 lessen production of heat, and those which increase loss of 

 heat ; and these again are subdivided, as shown in the 

 following table : 



Quinine 

 and 



Cinchona Alkaloids. 



Alcohol. 



'By lessening tissue change : 



Lessen pro- 

 duction of < 

 heat. 



By depressing the circula- f Aconite 

 tion : \ 



I 



Increase 

 of heat. 



By acting on the heat regula- 

 ting centre (Antipyretics) 

 and bringing about dila- 

 tation of skin vessels and 

 sweating : 



Antipyrine. 

 Antifebrin. 

 Phenacetin. 

 Carbolic Acid. 

 Salicylic Acid. 



By dilating cutaneous ves- 



sels and so increasing Alcohol 

 radiation : 



By causing sweating: 

 phoretics : 



Dia-/ P - ilocarpine - 



By abstracting heat from 

 the body : 



Nitrites. 

 I Ipecacuanha. 



Cold Baths. 



Cold Sponging. 



Wet Packs. 



Ice. 



Cold Drinks 



Enemata. 

 Purgatives. 

 Diuretics. 

 Venesection. 



and 



