SALOL 401 



suffering from diabetes, being given in quantities of one-fifth 

 to half a grain. An elixir is made with saccharin, twenty- 

 four grains, sodium bicarbonate, twelve grains, rectified 

 spirit, one drachm, distilled water, seven drachms. Twenty 

 minims contain one grain of saccharin. 



SALOL, or phenyl salicylate, is prepared by the interaction 

 of salicylic acid and phenol. It occurs as a crystalline 

 white powder, with an aromatic smell and insipid taste. 

 Insoluble in glycerin or water, but soluble in ten parts alcohol, 

 less than one of ether, chloroform, or benzene ; and in the 

 fixed oils. The actions and uses are those of its two com- 

 ponents. It is antiseptic, analgesic, antipyretic, and an 

 intestinal disinfectant. It is not so irritant as salicylic 

 acid, and only poisons in large doses. It is eliminated in 

 the urine as salicylic acid and sulphophenol. By the saliva, 

 the pancreatic and intestinal juices, it is resolved into 

 salicylic and carbolic acids, which, with their products, 

 can be detected in the urine. It checks undue fermentation 

 in the digestive canal, and is serviceable in diarrhoea. 

 Frohner recommends it as an anti-rheumatic, especially 

 in dogs ; but neither in muscular nor arthritic rheumatism 

 does it appear to be so effectual as sodium salicylate. Kauf- 

 mann advises its use as a substitute for iodoform in surgical 

 cases, notably in diseases of the urino-genital organs, and 

 in otorrhcea, stomatitis, and ozaena. Horses take ^iii. to 

 3vi. ; dogs, grs. iii. to grs. xv., in pill or electuary. In acute 

 rheumatism these doses may be repeated two or three times 

 a day. For the several purposes of a non-irritant antiseptic 

 it is used as powder, liniment, or ointment, and with col- 

 lodion as an antiseptic adhesive. A useful dressing for 

 catheters consists of one part salol, and fifteen parts each of 

 castor oil and almond oil (G. B. Browne). 



SALACETOL, a salicylic ester of acetone, introduced as a 

 substitute for salol, which contains phenol. It contains 

 about seventy-five per cent, of salicylic acid, occurs in 

 shining crystals, insoluble in water, freely soluble in alcohol, 

 ether, and chloroform. It is employed as a disinfectant 

 for the digestive and urinary tracts. Doses, horses, 3 n - 

 to 3vi- 5 dogs, grs. iv. to grs. xx. 



PYOKTANIN (methyl violet) is a powerful antiseptic, pro- 



2c 



