462 PODOPHYLLTJM 



Dollar administered two drachms podophyllum in a ball, 

 and two ounces Epsom salt in solution. Scarcely any 

 perceptible action was observed on the bowels ; and two 

 days later two drachms podophyllum and one drachm 

 calomel were given, also without purgative effect, but 

 with a reduction in the pulse of nearly ten beats per 

 minute. 



A powerful cart-horse, under treatment for sand-crack, 

 and previously restricted for twenty-four hours to a mash 

 diet, received four drachms podophyllum resin in a ball. 

 Although no purgation followed, there was nausea, and in 

 two hours the pulse, soft and somewhat weakened, fell from 

 36 to 24, and did not recover its natural force or number 

 until next day. The appetite continued impaired for a 

 week. 



A Scotch terrier, eight months old, received half a grain 

 of the resin in a pill, without apparent effect ; and on the 

 foUowing day a grain, which in the course of an hour caused 

 nausea and vomiting. Considerable dulness remained for 

 twenty-four hours. 



A bull terrier bitch, thirty-six pounds weight, received 

 four grams in a pill, without showing any notable symptoms, 

 and on the following day had a further dose of six grains, 

 which in twelve hours produced great uneasiness, griping, 

 and gentle catharsis. During the two following days the 

 bitch refused food, and for a week continued dull and list- 

 less. 



A French poodle, suffering from mange and constipation,, 

 had a pill containing two grains podophyllum resin, half a 

 grain calomel, and twenty grains jalap. No effect was 

 observable at the end of twelve hours, when the dose was 

 repeated, and after eight hours the dog was briskly purged. 

 Half the above dose was repeated every second day for a 

 fortnight, with the result of gently moving the bowels. 

 In all these cases the pulse was reduced in number and in 

 strength, the urinary secretion was unchanged, and the 

 faeces were little altered in colour (Dollar). 



MEDICINAL USES. These experiments demonstrate that 

 for veterinary patients podophyllum resin is a tardy and 

 uncertain purgative, especially when used alone, and there 



