514 CALABAR BEAN SERVICEABLE IN 



and several ounces of a brown-coloured fluid will at this time 

 accompany each motion. About two to two and a half 

 hours from the time of injection the effects are commencing 

 to pass off, and during this short time an almost incredible 

 amount of fseces will have been excreted. 



'A horse received 1J grains of eserine, subcutaneously ; 

 it acted in twenty-five minutes, and produced in the first hour 

 seven evacuations, in the second hour seven, the effect 

 passing off in two hours and ten minutes. 



' A horse received 1 J grains of eserine, hypodermically, 

 which took twelve minutes to act, producing seven evacua- 

 tions in the first hour, and then terminating. 



' Another horse received 1J grains of salicylate of eserine, 

 hypodermically, producing a free action of the bowels in 

 one hour. This case terminated fatally from ruptured 

 stomach ; and thus it was demonstrated that eserine could 

 act upon the large intestine, in spite of the shock to 

 the abdominal nervous system which a ruptured stomach 

 causes. 



' A pony received 1 grain of eserine, hypodermically ; 

 three evacuations were produced in fifty minutes, and in 

 eighty minutes from the time of injection eight evacua- 

 tions had occurred. The case was a fatal one, the cause of 

 obstruction being due to a small diaphragmatic hernia. 

 Had the gut not been nipped so tightly, there is reason to 

 believe the increased peristalsis might have withdrawn it. 



' A horse received 1 J grains of eserine by injection into the 

 trachea ; it took seventeen minutes to act, and produced in 

 the first hour twelve evacuations, weighing 11 Ibs. 13 oz., 

 and a considerable quantity of flatus. The action then 

 passed off. 



' A horse received 1 grain of eserine, hypodermically ; it 

 took forty- two minutes to act, and produced only one 

 evacuation in one hour, accompanied by a considerable 

 quantity of flatus. 



' The same horse received 1 grain of eserine and 3 grains 

 of pilocarpine by injection into the trachea ; it took twenty- 

 one minutes to act. In the first hour, counting from time 

 of injection, it produced fourteen evacuations, weighing 

 30 Ibs. 6 oz. ; in the second hour four evacuations, weighing 



