564 CINCHONA QUININE 



sulphate, in doses of 240 to 350 grains, repeated if requisite, 

 is strongly recommended as a remedy for red water in cattle. 



Quinine is often employed in mala.rial diseases, and in rheu- 

 matism, being given either by the mouth or hypodermically, 

 frequently conjoined with salicylic acid or potassium iodide. 

 Dollar has successfully treated cases of rheumatism and 

 sciatica in horses, which have resisted other remedies, by 

 hypodermic injection into the affected muscles of half a 

 drachm of quinine sulphate in solution, and has not 

 found undue irritation or abscess follow the operation. Like 

 other bitters, when administered with cathartics, it generally 

 increases their activity. Alternated with cod-liver oil and 

 iron, quinine is the best tonic for weakly dogs and those 

 suffering from chorea. 



The alkaloids are seldom used as antiseptics for wounds, 

 but occasionally in the form of spray or gargle are applied 

 to relaxed or suppurating throat. 



DOSES, etc. Cinchona bark is prescribed in the following 

 doses : For horses, ^ii]. to i. ; cattle, 3 V J- to ij- 5 

 sheep and pigs,3i- to ^iv. ; dogs, grs. xx. to 3i- J cats, grs. v. 

 to grs. xx., repeated twice or thrice daily for several days. 

 If nausea or vomiting supervene, as occasionally happens in 

 dogs, the dose should be considerably reduced or intermitted 

 for a day or two. It is administered in bolus, pill, or solution, 

 and is often conjoined with camphor, gentian, ginger, spirit, 

 or ether. The infusion is made by digesting one part red 

 bark with one-fourth part aromatic sulphuric acid and twenty 

 parts water, and straining. The tincture, now standardised, 

 is made by maceration and percolation of 4 ounces red bark 

 in one pint of alcohol (70 per cent). It contains 1 per cent, 

 of alkaloids. The compound tincture, made with tincture 

 of cinchona, orange peel, serpentary, cochineal, saffron, 

 and alcohol (70 per cent.), is standardised to contain 0'5 

 per cent, of alkaloids. The liquid extract of cinchona 

 contains 5 per cent, of alkaloids. The salts of quinine 

 are prescribed in the following doses : Horses and cattle 

 (tonic), grs. xxx. to grs. xc. ; (febrifuge) grs. clx. to grs. ccxl. ; 

 sheep and pigs, grs. viii. to grs. xxx. ; dogs and cats, gr. i. 

 to grs. x. Cinchonine sulphate is given in double these 

 quantities. These doses, in bolus, pill, or solution, are 



