618 YOHIMBINE 



thesia, lasting for an hour or more, without mydriasis, or 

 alteration of the corneal epithelium. Yohimbine is chiefly 

 used as a remedy for functional impotence and sterility. 

 It appears to be eminently adapted as a means of reviving 

 the sexual powers of apparently healthy animals which have 

 become barren or impotent from prolonged continence or 

 some obscure cause. It has also been employed to arrest 

 obstinate vomiting in dogs, and in the treatment of spinal 

 paralysis in young horses. Holterbach, who first prescribed 

 it in veterinary practice, records the case of a bull which 

 for nine months had refused to cover. Various drugs 

 having been tried without benefit, the bull was given 

 yohimbine in his drinking water for ten days. He then 

 covered twice consecutively, and eleven days later served 

 again quite satisfactorily. Similar treatment of four other 

 bulls, unable or unwilling to cover, was followed by equally 

 good results. Cows, which had ceased to exhibit symptoms 

 of oestrum, and an impotent bull, were successfully treated 

 by the administration of gr. 1J to grs. 3 per day. Sub- 

 cutaneous injections of gr. ^ yohimbine, prescribed by 

 Kogan for a stallion which had been rendered impotent 

 by injury from a falling beam, rapidly restored sexual 

 power. Excellent results have been obtained by Paarl, 

 Simon, Haas, Manuel, and others in stallions, bulls, and 

 cows ; by Sewell, Paul, and Cowan in bitches ; and by 

 Holterbach in the sow. Yohimbine is non-cumulative, 

 and, unlike cantharides, it does not irritate the urinary 

 organs ; but as dogs have been poisoned with half a grain, 

 care should be exercised in prescribing this drug. The 

 symptoms of poisoning are dyspnoea, depression of the 

 heart, salivation, diarrhoea, falling temperature, partial 

 paralysis, and convulsions. 



Doses, etc. Stallions, gr. -| ; bulls, gr. 1J ; cows, gr. 1 ; 

 sheep, gr. J ; small dogs, gr. ^ to gr. ^ ; dogs, 

 weighing 20 to 50 Ibs., gr. ^ ; dogs over 50 Ibs., gr. \ ; 

 in food, drinking water, or in bolus or pill. These doses 

 may be repeated three times a day. Tablets containing 

 S r - A & r - J> anc * 8 r - * yohimbine for veterinary 

 patients are now obtainable. 



DAMIANA. The liquid extract of damiana prepared 



