698 BLACK QUARTER VACCINE 



by the Pasteur Institute and sent out in sealed vials contain- 

 ing 10 cubic centimetres and 20 cubic centimetres, preserves 

 its properties for a long time when kept in a cool, dark 

 place. Properly administered it confers immunity from 

 tetanus for about six weeks, and this period of protection 

 can be extended by successive injections. As a preventive 

 of tetanus its action is certain, but as a curative it has 

 little value in acute tetanus, though in the slowly developing 

 case it sometimes promotes recovery. As a prophylactic 

 tetanus antitoxin is indicated prior to or soon after dangerous 

 operations, and as early as possible in diseases or wounds 

 which may be considered as particularly exposed to infection 

 by the tetanus bacillus. It is usually administered sub- 

 cutaneously after careful disinfection of the skin at the point 

 of injection ; but intracranial injection, which assures 

 immediate action of the antitoxin on the nervous tissue, 

 should be preferred when practicable. It has been given 

 intravenously ; and occasionally it is injected into a wound 

 which may be suspected as the seat of primary infection. 



DOSES. Horses, 10 c.c. ; ponies, 3 c.c. to 5 c.c. ; two in- 

 jections should be given, the first just before or immediately 

 after the operation, the second in eight or ten days after 

 the first. As a curative, a first injection of 50 c.c. may be 

 given, and followed by injections of 20 c.c. daily for six 

 to eight days. 



The dried serum, which keeps indefinitely, is supplied 

 in tubes, each containing a quantity of powder corresponding 

 to 10 c.c. of the liquid serum. This preparation may be 

 sprinkled on operation or accidental wounds, or dissolved 

 in a little sterilised water and injected subcutaneously in 

 the same way as the liquid antitoxin. Applied to wounds 

 it exerts an antitetanic action and promotes healing 

 (Porcher). 



Antistreptococcic polyvalent serum is obtained from 

 horses which have been immunised against various types 

 of streptococci. It is supplied by the Pasteur Institute 

 in sealed vials, each containing 10 c.c. of liquid serum, 

 and in tubes containing an equivalent in powder. Anti- 

 streptococcic serum has been used more or less successfully 

 in the early stages of strangles, purpura, and distemper of 



