302 BACILLUS OF SWINE ERYSIPELAS 



injection. The doses recommended for hogs of different sizes are 

 the following: 



For hogs up to 50 pounds 3 c.c. antiserum 



For hogs from 50 to 100 pounds 5 c.c. antiserum 



For hogs from 100 to 250 pounds . 8 c.c. antiserum 



For hogs from 150 to 200 pounds 10 c.c. antiserum 



For hogs over 300 pounds 15 c.c. antiserum 



The bouillon culture employed for injection must be young and 

 virulent. It is used in doses of from 0.25 to 1 c.c., according to the 

 weight of the animal, but between these limits very great accuracy 

 in the dose is unnecessary. In the simultaneous method the immune 

 serum and the culture may be mixed, or they may be injected at the 

 same time in two different spots. When the serum is first injected 

 alone the culture must be injected after three to five days. The 

 passive immunization by the serum alone produces immunity for a 

 very short period only, but the combined passive and active immu- 

 nization protects the animals treated for a period variously estimated 

 at from six to twelve months. The statistics from France, Germany, 

 and Austria concerning the value of the combined protective inocu- 

 lation of hogs against erysipelas are very favorable. 



Transmission to Man. Preisz and other authors have reported a 

 few cases of persons who having handled hogs sick with erysipelas 

 or their meat, contracted a slight erysipeloid lesion of the skin, transi- 

 tory in character, and not leading to any grave general disturbances. 



THE BACILLUS OF MOUSE SEPTICEMIA. 



Koch, when studying wound infection diseases early in his career, 

 discovered a very minute bacillus, very fatal to mice, which he called 

 the Bacillus murisepticus, or the bacillus of mouse septicemia. After 

 Loeffler had discovered the bacillus of swine erysipelas it was found 

 that the latter and the bacillus of mouse septicemia were so similar in 

 morphologic and cultural properties that it appeared reasonable to 

 consider them as one species. The question, however, is not yet fully 

 settled. It is discussed by Preisz, who has given considerable attention 

 to this matter in his article on swine erysipelas. 1 Preisz's statements 

 are to the following effect. The question whether anybody has 

 succeeded in finding the bacillus of hog erysipelas in the outside 

 world is intimately connected with the question whether the bacillus 

 is identical with that of mouse septicemia. Koch found the bacillus 

 in putrefying fluids, Loeffler observed an epidemic among his mice 

 due to it, Johne cultivated it from putrid meat, and Preisz from 

 putrid cattle blood. 



The morphology and cultural properties of the Bacillus murisep- 



1 Kolle and Wassermann's Manual, vol. iii. 



