A LOCAL EQUINE DISEASE 397 



effect was produced in the inoculated animals. On the morning of the 

 fifth day guinea-pigs inoculated from cultures Nos. 1, 2, and 3 (each 

 from a different horse) were found dead. On the seventh day the 

 guinea-pig inoculated from stem No. 5 was found dead. Autopsies 

 on the dead animal showed no typical lesions. Cultures were made 

 from the heart's blood of the four dead guinea-pigs; in 3 cases an 

 organism identical with the one injected was obtained but the cultures 

 soon died out. One which remained alive after several transplants 

 was inoculated subcutaneously into a healthy horse. It failed to 

 produce any general reaction, the temperature of the horse was taken 

 regularly, and remained normal for a number of days. A slight local 

 reaction developed at the site of the injection (neck), but this dis- 

 appeared after a few days. In the bacteriologic part of this investiga- 

 tion the author was assisted by Dr. Conrad Jacobson. No definite 

 conclusion as to the relation of the bacillus obtained to the disease can 

 be drawn from the above results. Further and more extensive studies 

 are necessary. 





